Details:

Alternative Title:
Risk Anal
Publisher's site:
http://dx.doi.org/10.1111/risa.12762
Personal Author:
Wheeler, Matthew W. ; Bailer, A. John ; Cole, Tarah ; Park, Robert M. ; Shao, Kan
Wheeler, Matthew W. ; Bailer, A. John ; Cole, Tarah ; Park, Robert M. ; Shao, Kan Less -
Description:
Quantitative risk assessment often begins with an estimate of the exposure or dose associated with a particular risk level from which exposure levels posing low risk to populations can be extrapolated. For continuous exposures, this value, the benchmark dose, is often defined by a specified increase (or decrease) from the median or mean response at no exposure. This method of calculating the benchmark dose does not take into account the response distribution and, consequently, cannot be interpreted based upon probability statements of the target population. We investigate quantile regression as an alternative to the use of the median or mean regression. By defining the dose-response quantile relationship and an impairment threshold, we specify a benchmark dose as the dose associated with a specified probability that the population will have a response equal to or more extreme than the specified impairment threshold. In addition, in an effort to minimize model uncertainty, we use Bayesian monotonic semiparametric regression to define the exposure-response quantile relationship, which gives the model flexibility to estimate the quantal dose-response function. We describe this methodology and apply it to both epidemiology and toxicology data.
Subject:
[+]
Animal Toxicity Studies
Article
Monotone Smoothing Splines
Risk Assessment
Semiparametric Modeling

Source:
Risk Anal. 37(11):2107-2118.
Pubmed ID:
28555874
Pubmed Central ID:
PMC5740488
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5097c88424f90434cfdbb8f498a14d4c82a64458573717caf1180d440799edde
File Type:

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