Details:

Alternative Title:
Vaccine
Publisher's site:
http://dx.doi.org/10.1016/j.vaccine.2017.11.040
Personal Author:
Breakwell, Lucy ; Whaley, Melissa ; Khan, Unab I. ; Bandy, Utpala ; Alexander-Scott, Nicole ; ... More +
Breakwell, Lucy ; Whaley, Melissa ; Khan, Unab I. ; Bandy, Utpala ; Alexander-Scott, Nicole ; Dupont, Lynn ; Vanner, Cindy ; Chang, How-Yi ; Vuong, Jeni T. ; Martin, Stacey ; MacNeil, Jessica R. ; Wang, Xin ; Meyer, Sarah A. Less -
Description:
Objectives

Several outbreaks of serogroup B meningococcal disease have occurred among university students in recent years. In the setting of high coverage of the quadrivalent meningococcal conjugate vaccine and prior to widespread use of serogroup B meningococcal vaccines among adolescents, we conducted surveys to characterize the prevalence and molecular characteristics of meningococcal carriage among university students.

Methods

Two cross-sectional oropharyngeal carriage surveys were conducted among undergraduates at a Rhode Island university. Isolates were characterized using slide agglutination, real-time polymerase chain reaction (rt-PCR), and whole genome sequencing. Adjusted prevalence ratios and 95% confidence intervals were calculated using Poisson regression to determine risk factors for carriage.

Results

A total of 1837 oropharyngeal specimens were obtained from 1478 unique participants. Overall carriage prevalence was 12.7–14.6% during the two survey rounds, with 1.8–2.6% for capsular genotype B, 0.9–1.0% for capsular genotypes C, W, or Y, and 9.9–10.8% for nongroupable strains by rt-PCR. Meningococcal carriage was associated with being male, smoking, party or club attendance, recent antibiotic use (inverse correlation), and recent respiratory infections.

Conclusions

In this university setting, the majority of meningococcal carriage was due to nongroupable strains, followed by serogroup B. Further evaluation is needed to understand the dynamics of serogroup B carriage and disease among university students.


Subject:
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Article
Carriage
Meningococcal Disease
Meningococcal Infections
Meningococcal Vaccines
Neisseria Meningitidis

Source:
Vaccine. 36(1):29-35.
Pubmed ID:
29183735
Pubmed Central ID:
PMC5737556
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7aa56fc646c6cf3c22b14e6f702409cc7b995f535f12001e744a4e372ceaa712
File Type:

Supporting Files

• nihms927277.nxml

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