Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Belser, Jessica A. ; Creager, Hannah M. ; Zeng, Hui ; Maines, Taronna R. ; Tumpey, Terrence M.
• Description:
  H7 subtype influenza viruses represent a persistent public health threat because of their continued detection in poultry and ability to cause human infection. An outbreak of highly pathogenic avian influenza H7N7 virus in Italy during 2013 resulted in 3 cases of human conjunctivitis. We determined the pathogenicity and transmissibility of influenza A/Italy/3/2013 virus in mouse and ferret models and examined the replication kinetics of this virus in several human epithelial cell types. The moderate virulence observed in mammalian models and the capacity for transmission in a direct contact model underscore the need for continued study of H7 subtype viruses.
• Subjects:
  Animals Cells, Cultured Conjunctivitis, Viral Disease Models, Animal Endothelium, Corneal Female Ferrets Humans Influenza, Human Influenza A Virus, H7N7 Subtype Influenza In Birds Male Mice Mice, Inbred BALB C Nasal Mucosa Poultry Viral Tropism Virus Replication

  More +
• Source:
  J Infect Dis. 216(Suppl 4):S508-S511.
• Pubmed ID:
  28934452
• Pubmed Central ID:
  PMC5729276
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Italy
• Volume:
  216
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5ad523b0fe7b180cd46609c0e86c9eacdff9fc3bdeb33e556cfc5d90109b121c
• Download URL:
  https://stacks.cdc.gov/view/cdc/50542/cdc_50542_DS1.pdf
• File Type:
  [PDF - 566.01 KB ]