Details:

Alternative Title:
J Infect Dis
Personal Author:
Belser, Jessica A. ; Creager, Hannah M. ; Zeng, Hui ; Maines, Taronna R. ; Tumpey, Terrence M.
Belser, Jessica A. ; Creager, Hannah M. ; Zeng, Hui ; Maines, Taronna R. ; Tumpey, Terrence M. Less -
Description:
H7 subtype influenza viruses represent a persistent public health threat because of their continued detection in poultry and ability to cause human infection. An outbreak of highly pathogenic avian influenza H7N7 virus in Italy during 2013 resulted in 3 cases of human conjunctivitis. We determined the pathogenicity and transmissibility of influenza A/Italy/3/2013 virus in mouse and ferret models and examined the replication kinetics of this virus in several human epithelial cell types. The moderate virulence observed in mammalian models and the capacity for transmission in a direct contact model underscore the need for continued study of H7 subtype viruses.
Subject:
[+]
Animals
Article
Cell Culture
Cells, Cultured
Conjunctivitis
Conjunctivitis, Viral
Disease Models, Animal
Endothelium, Corneal
Female
Ferret
Ferrets
Humans
Influenza
Influenza, Human
Influenza A Virus, H7N7 Subtype
Influenza In Birds
Italy
Male
Mice
Mice, Inbred BALB C
Mouse
Nasal Mucosa
Poultry
Transmission
Viral Tropism
Virus Replication

Source:
J Infect Dis. 216(Suppl 4):S508-S511.
Pubmed ID:
28934452
Pubmed Central ID:
PMC5729276
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5ad523b0fe7b180cd46609c0e86c9eacdff9fc3bdeb33e556cfc5d90109b121c
File Type:

Supporting Files

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