Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013

Belser, Jessica A.; Creager, Hannah M.; Zeng, Hui; Maines, Taronna R.; Tumpey, Terrence M.

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Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013

Published Date:

Sep 15 2017

Source:

J Infect Dis. 216(Suppl 4):S508-S511.

[PDF-566.01 KB]

Details:

Alternative Title:

J Infect Dis

Personal Author:

Belser, Jessica A. ; Creager, Hannah M. ; Zeng, Hui ; Maines, Taronna R. ; Tumpey, Terrence M. ;

Description:

H7 subtype influenza viruses represent a persistent public health threat because of their continued detection in poultry and ability to cause human infection. An outbreak of highly pathogenic avian influenza H7N7 virus in Italy during 2013 resulted in 3 cases of human conjunctivitis. We determined the pathogenicity and transmissibility of influenza A/Italy/3/2013 virus in mouse and ferret models and examined the replication kinetics of this virus in several human epithelial cell types. The moderate virulence observed in mammalian models and the capacity for transmission in a direct contact model underscore the need for continued study of H7 subtype viruses.

Subject:

[+]

Pubmed ID:

28934452

Pubmed Central ID:

PMC5729276

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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