Influenza Vaccine Effectiveness Against Pediatric Deaths: 2010–2014

Flannery, Brendan; Reynolds, Sue B.; Blanton, Lenee; Santibanez, Tammy A.; O’Halloran, Alissa; Lu, Peng-Jun; Chen, Jufu; Foppa, Ivo M.; Gargiullo, Paul; Bresee, Joseph; Singleton, James A.; Fry, Alicia M

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Influenza Vaccine Effectiveness Against Pediatric Deaths: 2010–2014

Apr 03 2017
By Flannery, Brendan ; Reynolds, Sue B. ; Blanton, Lenee ; ...
Source: Pediatrics. 139(5).

[PDF-402.35 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Pediatrics
Personal Author:

Flannery, Brendan ; Reynolds, Sue B. ; Blanton, Lenee ; Santibanez, Tammy A. ; O’Halloran, Alissa ; ... More +

Flannery, Brendan ; Reynolds, Sue B. ; Blanton, Lenee ; Santibanez, Tammy A. ; O’Halloran, Alissa ; Lu, Peng-Jun ; Chen, Jufu ; Foppa, Ivo M. ; Gargiullo, Paul ; Bresee, Joseph ; Singleton, James A. ; Fry, Alicia M Less -
Description:

BACKGROUND AND OBJECTIVE

Surveillance for laboratory-confirmed influenza-associated pediatric deaths since 2004 has shown that most deaths occur in unvaccinated children. We assessed whether influenza vaccination reduced the risk of influenza-associated death in children and adolescents.

METHODS

We conducted a case-cohort analysis comparing vaccination uptake among laboratory-confirmed influenza-associated pediatric deaths with estimated vaccination coverage among pediatric cohorts in the United States. Case vaccination and high-risk status were determined by case investigation. Influenza vaccination coverage estimates were obtained from national survey data or a national insurance claims database. We estimated odds ratios (OR) from logistic regression comparing odds of vaccination among cases with odds of vaccination in comparison cohorts. We used Bayesian methods to compute 95% credible intervals for vaccine effectiveness (VE), calculated as (1 – OR) × 100.

RESULTS

From August 2010 through July 2014, 358 laboratory-confirmed influenza-associated pediatric deaths were reported among children aged 6 months through 17 years. Vaccination status was determined for 291 deaths; 75 (26%) received vaccine before illness onset. Average vaccination coverage in survey cohorts was 48%. Overall VE against death was 65% (95% credible interval: 54–73). Among 153 deaths in children with underlying high-risk medical conditions, 47 (31%) were vaccinated. VE among children with high-risk conditions was 51% (95% credible interval: 31-67), versus 65% (95% credible interval: 47-78) among children without high-risk conditions.

CONCLUSIONS

Influenza vaccination was associated with reduced risk of laboratory-confirmed influenza-associated pediatric death. Increasing influenza vaccination could prevent influenza-associated deaths among children and adolescents.
Subjects:

[+]

Adolescent Child Cohort Studies Humans Influenza, Human Influenza Vaccines Mass Vaccination
Source:

Pediatrics. 139(5).
Pubmed ID:

28557757
Pubmed Central ID:

PMC5728382
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Place as Subject:

United States
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:013b968f8ce5e7328ff7855f5b195023d4bb6988c199c375f6646dd32d7a74ec
Download URL:

https://stacks.cdc.gov/view/cdc/50536/cdc_50536_DS1.pdf
File Type:

	nihms924178.nxml	xml
	nihms924178f1.gif	gif
	nihms924178f1.jpg	jpeg

More +