Details:

Alternative Title:
Drug Discov Today
Publisher's site:
http://dx.doi.org/10.1016/j.drudis.2016.11.020
Personal Author:
Nassar, Ala F. ; Wu, Terence ; Nassar, Samuel F. ; Wisnewski, Adam V.
Nassar, Ala F. ; Wu, Terence ; Nassar, Samuel F. ; Wisnewski, Adam V. Less -
Description:
Metabolomics is a relatively new and rapidly growing area of post-genomic biological research. As use of metabolomics technology grows throughout the spectrum of drug discovery and development, and its applications broaden, its impact is expanding dramatically. This review seeks to provide the reader with a brief history of the development of metabolomics, its significance and strategies for conducting metabolomics studies. The most widely used analytical tools for metabolomics: NMR, LC-MS and GC-MS, are discussed along with considerations for their use. Herein, we will show how metabolomics can assist in pharmaceutical research studies, such as pharmacology and toxicology, and discuss some examples of the importance of metabolomics analysis in research and development.
Subject:
[+]
Article
Drug Discovery And Development
Mass Spectrometry
Metabolomics
Ultraperformance Liquid Chromatography

Source:
Drug Discov Today. 22(2):463-470.
Pubmed ID:
27919805
Pubmed Central ID:
PMC5721520
Document Type:
Journal Article
Funding:
R01 OH010941/OH/NIOSH CDC HHS/United States ; R21 OH010438/OH/NIOSH CDC HHS/United States
R01 OH010941/OH/NIOSH CDC HHS/United States ; R21 OH010438/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:50efdda130af2fb5d6d0976dd98a7269b5c74c4337d49a3ed7cf824b6656fbd3
File Type:

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