Details:

Alternative Title:
Clin Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/cid/cix468
Personal Author:
Arriola, Carmen ; Garg, Shikha ; Anderson, Evan J ; Ryan, Patrician A ; George, Andrea ; ... More +
Arriola, Carmen ; Garg, Shikha ; Anderson, Evan J ; Ryan, Patrician A ; George, Andrea ; Zansky, Shelley M ; Bennett, Nancy ; Reingold, Arthur ; Bargsten, Marisa ; Miller, Lisa ; Yousey-Hindes, Kimberly ; Tatham, Lilith ; Bohm, Susan R ; Lynfield, Ruth ; Thomas, Ann ; Lindegren, Mary Lou ; Schaffner, William ; Fry, Alicia M. ; Chaves, Sandra S. Less -
Description:
Background

We investigated the effect of influenza vaccination on disease severity in adults hospitalized with laboratory-confirmed influenza during 2013–14, a season in which vaccine viruses were antigenically similar to those circulating.

Methods

We analyzed data from the 2013–14 influenza season and used propensity score matching to account for the probability of vaccination within age strata (18–49, 50–64, and ≥65 years). Death, intensive care unit (ICU) admission, and hospital and ICU lengths of stay (LOS) were outcome measures for severity. Multivariable logistic regression and competing risk models were used to compare disease severity between vaccinated and unvaccinated patients, adjusting for timing of antiviral treatment and time from illness onset to hospitalization.

Results

Influenza vaccination was associated with a reduction in the odds of in-hospital death among patients aged 18–49 years (adjusted odds ratios [aOR] = 0.21; 95% confidence interval [CI], 0.05 to 0.97), 50–64 years (aOR = 0.48; 95% CI, 0.24 to 0.97), and ≥65 years (aOR = 0.39; 95% CI, 0.17 to 0.66). Vaccination also reduced ICU admission among patients aged 18–49 years (aOR = 0.63; 95% CI, 0.42 to 0.93) and ≥65 years (aOR = 0.63; 95% CI, 0.48 to 0.81), and shortened ICU LOS among those 50–64 years (adjusted relative hazards [aRH] = 1.36; 95% CI, 1.06 to 1.74) and ≥65 years (aRH = 1.34; 95% CI, 1.06 to 1.73), and hospital LOS among 50–64 years (aRH = 1.13; 95% CI, 1.02 to 1.26) and ≥65 years (aRH = 1.24; 95% CI, 1.13 to 1.37).

Conclusions

Influenza vaccination during 2013–14 influenza season attenuated adverse outcome among adults that were hospitalized with laboratory-confirmed influenza.


Subject:
[+]
Adolescent
Adult
Adults
Aged
Article
Disease Severity
Female
Humans
Influenza, Human
Influenza Vaccination
Influenza Vaccines
Male
Middle Aged
Propensity Score
Retrospective Studies
Severity Of Illness Index
Vaccination
Young Adult

Source:
Clin Infect Dis. 65(8):1289-1297.
Pubmed ID:
28525597
Pubmed Central ID:
PMC5718038
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; U38 OT000143/OT/OSTLTS CDC HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States
CC999999/Intramural CDC HHS/United States ; U38 OT000143/OT/OSTLTS CDC HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:597ebb0fbc1058be4af5a7c1434a9bc5a506e9aa9fb9c67f7c535917a4c0ecb9
File Type:

Supporting Files

• 	NIHMS920899-supplement-Supplemental_Table.docx	docx
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