Intelligence and academic achievement with asymptomatic congenital cytomegalovirus infection

Details

• Alternative Title:
  Pediatrics
• Personal Author:
  Lopez, Adriana S. ; Lanzieri, Tatiana M. ; Claussen, Angelika H. ; Vinson, Sherry S. ; Turcich, Marie ; Iovino, Isabella ; Voigt, Robert G. ; Caviness, A. Chantal ; Miller, Jerry A. ; Williamson, W. Daniel ; Hales, Craig M. ; Bialek, Stephanie R. ; Demmler-Harrison, Gail
• Description:
  Objectives
  
  To examine intelligence, language, and academic achievement through 18 years of age among children with congenital CMV infection identified through hospital-based newborn screening who were asymptomatic at birth compared to uninfected infants.
  
  Methods
  
  We used growth curve modeling to analyze trends in intelligence quotient (full-scale, verbal and non-verbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for case-patients with normal hearing (n=78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age (n=11) and controls (n=40).
  
  Results
  
  Case-patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared to controls, but no significant differences were noted in these scores among case-patients with normal hearing and controls. No significant differences were noted in scores for verbal and non-verbal intelligence, expressive vocabulary, and academic achievement in math and reading among case-patients with normal hearing or with SNHL and controls.
  
  Conclusions
  
  Infants with asymptomatic congenital CMV infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in intelligence quotient, vocabulary or academic achievement scores during childhood or adolescence compared with uninfected children.
  
  
• Subjects:
  Academic Achievement Adolescent Adult Article Asymptomatic Diseases Child Child, Preschool Congenital Cytomegalovirus Cytomegalovirus Infections Educational Status Female Humans Infant Infant, Newborn Intelligence Intelligence Tests Language Longitudinal Studies Male Middle Aged Neonatal Screening Sensorineural Hearing Loss Young Adult

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• Source:
  Pediatrics. 140(5).
• Pubmed ID:
  29066580
• Pubmed Central ID:
  PMC5654402
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States
• Volume:
  140
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ad8657eac2189d1182f5a44b4f1c0c0e87d44326f6f37d334e65ae943a545fb9
• Download URL:
  https://stacks.cdc.gov/view/cdc/50377/cdc_50377_DS1.pdf
• File Type:
  [PDF - 83.76 KB ]