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Detecting biomarkers of secondhand marijuana smoke in young children

Supporting Files
File Language:
English


Details

  • Alternative Title:
    Pediatr Res
  • Personal Author:
    Wilson, Karen M. ; Torok, Michelle R. ; Wei, Binnian ; Wang, Lanqing ; Robinson, Michelle ; Sosnof, Connie S. ; Blount, Benjamin C.
  • Description:
    Background

    The impact of secondhand marijuana smoke exposure on children is unknown. New methods allow detection of secondhand marijuana smoke in children.

    Methods

    We studied children ages 1 mo to 2 y hospitalized with bronchiolitis in Colorado from 2013 to 2015. Parents completed a survey, and urine samples were analyzed for cotinine using LC/MS/MS (limits of detection 0.03 ng/ml) and marijuana metabolites including COOH-THC (limits of detection 0.015 ng/ml).

    Results

    A total of 43 subjects had urine samples available for analysis. Most (77%) of the subjects were male, and 52% were less than 1 y of age. COOH-THC was detectable in 16% of the samples analyzed (THC+); the range in COOH-THC concentration was 0.03–1.5 ng/ml. Two subjects had levels >1 ng/ml. Exposure did not differ by gender or age. Non-white children had more exposure than white children (44 vs. 9%; P < 0.05). 56% of children with cotinine >2.0 ng/ml were THC+, compared with 7% of those with lower cotinine (P < 0.01).

    Conclusion

    Metabolites of marijuana smoke can be detected in children; in this cohort, 16% were exposed. Detectable COOH-THC is more common in children with tobacco smoke exposure. More research is needed to assess the health impacts of marijuana smoke exposure on children and inform public health policy.
  • Subjects:
  • Source:
    Pediatr Res. 81(4):589-592.
  • Pubmed ID:
    27911435
  • Pubmed Central ID:
    PMC5701510
  • Document Type:
    Journal Article
  • Funding:
    CC999999/Intramural CDC HHS/United States
  • Place as Subject:
    Colorado
  • Volume:
    81
  • Issue:
    4
  • Download URL:
    https://stacks.cdc.gov/view/cdc/49985/cdc_49985_DS1.pdf
  • File Type:
    Filetype[PDF - 306.53 KB]
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
    urn:sha256:13163978bd5eeec18c5eaa2215c3bcbbc1d5a057fa3ace8da43acc3ffac67a35

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