Details:

Alternative Title:
J Travel Med
Personal Author:
Stevens, A. Michal ; Esposito, Douglas H. ; Stoney, Rhett J. ; Hamer, Davidson H. ; Flores-Figueroa, Jose ; ... More +
Stevens, A. Michal ; Esposito, Douglas H. ; Stoney, Rhett J. ; Hamer, Davidson H. ; Flores-Figueroa, Jose ; Bottieau, Emmanuel ; Connor, Bradley A. ; Gkrania-Klotsas, Effrossyni ; Goorhuis, Abraham ; Hynes, Noreen A. ; Libman, Michael ; Lopez-Velez, Rogelio ; McCarthy, Anne E. ; von Sonnenburg, Frank ; Schwartz, Eli ; van Genderen, Perry J.J. ; Benson, L. Scott ; Leung, Daniel T. Less -
Corporate Authors:
for the GeoSentinel Surveillance Network
Description:
Background

There is increasing recognition of the contribution of community-acquired cases to the global burden of Clostridium difficile infection (CDI). The epidemiology of CDI among international travellers is poorly understood, and factors associated with international travel, such as antibiotic use and changes in gut microbiota, could potentially put travellers at higher risk.

Methods

We summarized demographic, travel-associated and geographic characteristics of travellers with CDI in the GeoSentinel database from 1997 to 2015. We also surveyed GeoSentinel sites to compare various testing indications, approaches, and diagnostic modalities.

Results

We identified 260 GeoSentinel records, including 187 that satisfied criteria for analysis (confirmed cases in non-immigrant travellers aged >2 years, seen <12 weeks post-travel). CDI was reported in all age groups and in travellers to all world regions; the largest proportions of cases having destinations in Asia (31%), Central/South America or the Caribbean (30%) and Africa (24%). Our site survey revealed substantial heterogeneity of testing approaches between sites; the most commonly used test was the C. difficile toxin gene PCR.

Conclusions

CDI is encountered in returning international travellers, although there is considerable variability in testing practices. These data underscore the importance of awareness of C. difficile as a potential cause of travel-associated diarrhoea.


Subjects:
[+]
Adolescent Adult Aged Aged, 80 And Over Article Child Child, Preschool Clostridioides Difficile Clostridium Difficile Clostridium Infections Diarrhoea Female Global Health Humans Male Middle Aged Population Surveillance Travellers Travel Medicine Young Adult
Source:
J Travel Med. 24(3)
Pubmed ID:
28355613
Pubmed Central ID:
PMC5697897
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; G0701652/MRC_/Medical Research CouncilUnited Kingdom/
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; G0701652/MRC_/Medical Research CouncilUnited Kingdom/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ce6f75d4b650d57b3623f03106a89a0eab9a8a1898880d88541d3883eacf2e89
Download URL:
https://stacks.cdc.gov/view/cdc/49945/cdc_49945_DS1.pdf
File Type:

Supporting Files

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