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Implementing Isoniazid Preventive Therapy in a TB-treatment experienced cohort on ART
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5 01 2017
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Source: Int J Tuberc Lung Dis. 21(5):537-543
Details:
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Alternative Title:Int J Tuberc Lung Dis
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Personal Author:
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Description:SETTING
Urban clinical research site in Durban, South Africa
OBJECTIVE
To describe the outcomes associated with implementation of isoniazid preventive therapy (IPT) in a cohort of TB treatment experienced HIV infected patients on antiretroviral therapy (ART).
DESIGN
We conducted a secondary analysis of data collected between October 2009 and October 2013 from patients enrolled in a prospective cohort study conducted in Durban, South Africa.
RESULTS
There were 402 patients enrolled in the parent study. Of these 344 (85.6%) were eligible to receive IPT and of whom 212 (61.6%) initiated IPT. Among those that initiated IPT, 184 (86.8%) completed the six month course, 24 (11.3%) permanently discontinued IPT and of these, 3.8% discontinued due to side effects. More women (n=130; 61.3%) initiated IPT (p=0.001) than men. Overall median adherence to IPT was 97.6% (IQR: 94.2 – 99.4). There were 22 cases of incident TB in this cohort: 13 occurred prior to IPT and nine after IPT (incidence rate ratio 0.67; 95% CI 0.29–1.58; p=0.362).
CONCLUSIONS
IPT implementation amongst ART and TB treatment experienced patients was well tolerated with good completion rates and fewer TB cases diagnosed after IPT exposure.
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Keywords:
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Source:
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Pubmed ID:28399969
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Pubmed Central ID:PMC5696541
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Document Type:
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Funding:
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Volume:21
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Issue:5
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File Type:
[PDF-347.37 KB]
