Contribution of solid organ transplant recipients to the pediatric non-Hodgkin lymphoma burden in the United States

Details

• Alternative Title:
  Cancer
• Personal Author:
  Yanik, Elizabeth L. ; Shiels, Meredith S. ; Smith, Jodi M. ; Clarke, Christina A. ; Lynch, Charles F. ; Kahn, Amy R. ; Koch, Lori ; Pawlish, Karen S. ; Engels, Eric A.
• Description:
  Background
  
  Pediatric solid organ transplant recipients have 100–200 times higher risk of non-Hodgkin lymphoma (NHL) than the general pediatric population. Consequently, transplant-related NHLs may contribute considerably to the pediatric NHL burden in the US.
  
  Methods
  
  We conducted a cohort study using a linkage between the US transplant registry and 16 cancer registries. We calculated cancer incidence rates among people <20 years old in the transplant and general populations. Rates were applied to transplant registry and US census data to estimate pediatric NHL counts in transplant recipients and the general population.
  
  Results
  
  During 1990–2012, an estimated 22,270 NHLs were diagnosed in US children and adolescents, including 628 diagnoses in transplant recipients. Thus, 2.82% (95%CI=2.45–3.19%) of pediatric NHL diagnoses in the general population occurred in transplant recipients. Among transplant recipients, the most common subtypes were diffuse large B-cell lymphoma (DLBCL, 64.5% of cases) and Burkitt lymphoma (8.6%). For DLBCL and Burkitt lymphoma, transplant recipients contributed 7.62%, (95%CI=6.35–8.88%) and 0.87% (95%CI=0.51–1.23%) of diagnoses, respectively. The proportion of NHLs that occurred in transplant recipients was highest among children <5 years old (4.46%, 95%CI=3.24–5.69%) and in more recent calendar years (2010–2012: 3.73%, 95%CI=2.07–5.39%). DLBCL patterns were similar with transplant recipients contributing 19.78% of cases in children <5 years old (95%CI=12.89–26.66%) and 11.4% of cases in 2010–2012 (95%CI=5.54–17.28%).
  
  Conclusions
  
  Among children and adolescents, solid organ transplant recipients contribute a substantial fraction of NHL diagnoses, particularly for DLBCL. This fraction has increased over time. Prevention efforts targeted towards this group could reduce the overall pediatric NHL burden.
  
  
• Subjects:
  Adolescent Adult Article Child Child, Preschool Cohort Studies Diffuse Large B-cell Lymphoma Epidemiology Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Lymphoma, Large B-Cell, Diffuse Male Neoplasm Staging Non-Hodgkin Lymphoma Organ Transplantation Pediatrics Prognosis Transplant Recipients United States Young Adult

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• Source:
  Cancer. 123(23):4663-4671
• Pubmed ID:
  28759103
• Pubmed Central ID:
  PMC5693631
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHS/United States ; HHSN261201000037C/CA/NCI NIH HHS/United States ; Z01 CP010176-07/NULL/Intramural NIH HHS/United States ; N01PC35143/CA/NCI NIH HHS/United States ; HHSN261201000032C/CA/NCI NIH HHS/United States ; HHSN261201300019C/CA/NCI NIH HHS/United States ; U58 DP003883/DP/NCCDPHP CDC HHS/United States ; Z99 CA999999/NULL/Intramural NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; Z01 CP010150-09/NULL/Intramural NIH HHS/United States ; U58 DP003875/DP/NCCDPHP CDC HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; HHSN261201000036C/CA/NCI NIH HHS/United States ; U58 DP003879/DP/NCCDPHP CDC HHS/United States ; N01PC35137/CA/NCI NIH HHS/United States ; N01CP45503/CP/NCI NIH HHS/United States ; HHSN261201300071C/CA/NCI NIH HHS/United States ; U58 DP003920/DP/NCCDPHP CDC HHS/United States ; HHSN261201300011C/RC/CCR NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; N01PC35142/CA/NCI NIH HHS/United States ; HHSN261201300021C/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; U58 DP000848/DP/NCCDPHP CDC HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003921/DP/NCCDPHP CDC HHS/United States ; HHSN261201300011I/CA/NCI NIH HHS/United States ; U58 DP000832/DP/NCCDPHP CDC HHS/United States ; N01PC35139/CA/NCI NIH HHS/United States ; U58 DP000824/DP/NCCDPHP CDC HHS/United States ; Z01 CP010150-08/NULL/Intramural NIH HHS/United States
• Volume:
  123
• Issue:
  23
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b0cc242d893eb4c723a7458e03dd1506adfa5dd52534382910d294cc8845fbb9
• Download URL:
  https://stacks.cdc.gov/view/cdc/49926/cdc_49926_DS1.pdf
• File Type:
  [PDF - 155.43 KB ]