Contribution of solid organ transplant recipients to the pediatric non-Hodgkin lymphoma burden in the United States

Details

• Alternative Title:
  Cancer
• Personal Author:
  Yanik, Elizabeth L. ; Shiels, Meredith S. ; Smith, Jodi M. ; Clarke, Christina A. ; Lynch, Charles F. ; Kahn, Amy R. ; Koch, Lori ; Pawlish, Karen S. ; Engels, Eric A.
• Description:
  Background ; Pediatric solid organ transplant recipients have 100–200 times higher risk of non-Hodgkin lymphoma (NHL) than the general pediatric population. Consequently, transplant-related NHLs may contribute considerably to the pediatric NHL burden in the US. ; Methods ; We conducted a cohort study using a linkage between the US transplant registry and 16 cancer registries. We calculated cancer incidence rates among people <20 years old in the transplant and general populations. Rates were applied to transplant registry and US census data to estimate pediatric NHL counts in transplant recipients and the general population. ; Results ; During 1990–2012, an estimated 22,270 NHLs were diagnosed in US children and adolescents, including 628 diagnoses in transplant recipients. Thus, 2.82% (95%CI=2.45–3.19%) of pediatric NHL diagnoses in the general population occurred in transplant recipients. Among transplant recipients, the most common subtypes were diffuse large B-cell lymphoma (DLBCL, 64.5% of cases) and Burkitt lymphoma (8.6%). For DLBCL and Burkitt lymphoma, transplant recipients contributed 7.62%, (95%CI=6.35–8.88%) and 0.87% (95%CI=0.51–1.23%) of diagnoses, respectively. The proportion of NHLs that occurred in transplant recipients was highest among children <5 years old (4.46%, 95%CI=3.24–5.69%) and in more recent calendar years (2010–2012: 3.73%, 95%CI=2.07–5.39%). DLBCL patterns were similar with transplant recipients contributing 19.78% of cases in children <5 years old (95%CI=12.89–26.66%) and 11.4% of cases in 2010–2012 (95%CI=5.54–17.28%). ; Conclusions ; Among children and adolescents, solid organ transplant recipients contribute a substantial fraction of NHL diagnoses, particularly for DLBCL. This fraction has increased over time. Prevention efforts targeted towards this group could reduce the overall pediatric NHL burden.
• Subjects:
  • Article
  • non-Hodgkin lymphoma
  • pediatrics
  • organ transplantation
  • epidemiology
  • diffuse large B-cell lymphoma
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
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• Source:
  Cancer. 123(23):4663-4671
• Pubmed ID:
  28759103
• Pubmed Central ID:
  PMC5693631
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHS/United States ; HHSN261201000037C/CA/NCI NIH HHS/United States ; Z01 CP010176-07/NULL/Intramural NIH HHS/United States ; N01PC35143/CA/NCI NIH HHS/United States ; HHSN261201000032C/CA/NCI NIH HHS/United States ; HHSN261201300019C/CA/NCI NIH HHS/United States ; U58 DP003883/DP/NCCDPHP CDC HHS/United States ; Z99 CA999999/NULL/Intramural NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; Z01 CP010150-09/NULL/Intramural NIH HHS/United States ; U58 DP003875/DP/NCCDPHP CDC HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; HHSN261201000036C/CA/NCI NIH HHS/United States ; U58 DP003879/DP/NCCDPHP CDC HHS/United States ; N01PC35137/CA/NCI NIH HHS/United States ; N01CP45503/CP/NCI NIH HHS/United States ; HHSN261201300071C/CA/NCI NIH HHS/United States ; U58 DP003920/DP/NCCDPHP CDC HHS/United States ; HHSN261201300011C/RC/CCR NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; N01PC35142/CA/NCI NIH HHS/United States ; HHSN261201300021C/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; U58 DP000848/DP/NCCDPHP CDC HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003921/DP/NCCDPHP CDC HHS/United States ; HHSN261201300011I/CA/NCI NIH HHS/United States ; U58 DP000832/DP/NCCDPHP CDC HHS/United States ; N01PC35139/CA/NCI NIH HHS/United States ; U58 DP000824/DP/NCCDPHP CDC HHS/United States ; Z01 CP010150-08/NULL/Intramural NIH HHS/United States
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• Volume:
  123
• Issue:
  23
• Download URL:
  https://stacks.cdc.gov/view/cdc/49926/cdc_49926_DS1.pdf
• File Type:
  [PDF - 155.43 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b0cc242d893eb4c723a7458e03dd1506adfa5dd52534382910d294cc8845fbb9