An invisible threat: mutation-mediated resistance to triazole drugs in Aspergillus

Details

• Alternative Title:
  Curr Fungal Infect Rep
• Personal Author:
  Pham, Cau D. ; Lockhart, Shawn R.
• Description:
  Aspergillosis has emerged as an important contributor to infection-related morbidity and mortality in susceptible populations. This comes at a time when we are also seeing an increase in the vulnerable populations themselves. At the same time, some parts of the world are reporting an increased incidence of aspergillosis refractory to triazole therapy. Resistance to triazole drugs may have major implications for aspergillosis management since our antifungal armamentarium is limited. This review gives an overview of populations at risk of developing aspergillosis and highlights resistance mechanisms that may contribute to morbidity and mortality in these vulnerable populations.
• Subjects:
  Article
• Source:
  Curr Fungal Infect Rep. 6(4):288-295
• Pubmed ID:
  29118894
• Pubmed Central ID:
  PMC5672947
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  6
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:047fa36ca14d2573e2ab8c0fd1c47af9abd270617a85e07045fd5d09164f302e
• Download URL:
  https://stacks.cdc.gov/view/cdc/49916/cdc_49916_DS1.pdf
• File Type:
  [PDF - 324.12 KB ]