Prevalence of renal impairment and associated conditions among HCV-infected persons in the Chronic Hepatitis Cohort Study (CHeCS)

Details

• Alternative Title:
  Dig Dis Sci
• Personal Author:
  Moorman, Anne C. ; Tong, Xin ; Spradling, Philip R. ; Rupp, Loralee B. ; Gordon, Stuart C. ; Lu, Mei ; Teshale, Eyasu H. ; Boscarino, Joseph A. ; Trinacty, Connie M. ; Schmidt, Mark A. ; Xu, Fujie ; Holmberg, Scott D.
  More +
• Description:
  Background ; Guidelines for the treatment of HCV-infected persons were updated in August 2015 with new recommendations for patients with renal impairment. Treatment is imperative for patients with severe, renal-associated extrahepatic manifestations of HCV infection. ; Aims ; We sought to describe the prevalence of these conditions among current HCV-infected patients in a population-based prospective, observational cohort study at four large US health systems. ; Methods ; Data from cohort patients with chronic HCV infection during 2012 were analyzed for the period from 2006–2013. We determined the prevalence of mild-moderately impaired renal function defined as having the most recent estimated glomerular filtration rate eGFR <80 ml/min/1.73m2, with severe impairment defined as eGFR<30 ml/min/1.73m2, based on the treatment guidelines. Prevalence of extrahepatic conditions were ascertained using ICD9-codes. ; Results ; Among 5,772 persons the prevalence of eGFR<80 was 33% and eGFR<30 was 2%, including among patients with hepatic fibrosis. Diagnosed extrahepatic renal manifestations were rare: vasculitis- 0.2%, nephrotic syndrome- 0.3%, and cryoglobulinemia- 0.9%. ; Conclusions ; While the prevalence of severe renal impairment and diagnosed extrahepatic manifestations were low, mild-to-moderate renal impairment was common in HCV patients, including those with advanced liver fibrosis for whom the need for treatment is urgent.
• Subjects:
  • Adult
  • Aged
  • Female
  • Hepatitis C, Chronic
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Renal Insufficiency
• Keywords:
  • hepatitis C
  • renal disease
  • glomerular filtration rate
  • hepatic fibrosis
• Source:
  Dig Dis Sci. 61(7):2087-2093
• Pubmed ID:
  27216163
• Pubmed Central ID:
  PMC5675517
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; U18 PS005154/PS/NCHHSTP CDC HHSUnited States/
• Volume:
  61
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/49665/cdc_49665_DS1.pdf
• File Type:
  [PDF - 78.90 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:21502696a9699825629b14a421a0b3829b72d920c6b6552cb8e4199bac1e97c4