Details:

Alternative Title:
Dig Dis Sci
Personal Author:
Moorman, Anne C. ; Tong, Xin ; Spradling, Philip R. ; Rupp, Loralee B. ; Gordon, Stuart C. ; ... More +
Moorman, Anne C. ; Tong, Xin ; Spradling, Philip R. ; Rupp, Loralee B. ; Gordon, Stuart C. ; Lu, Mei ; Teshale, Eyasu H. ; Boscarino, Joseph A. ; Trinacty, Connie M. ; Schmidt, Mark A. ; Xu, Fujie ; Holmberg, Scott D. ; Less -
Description:
Background Guidelines for the treatment of HCV-infected persons were updated in August 2015 with new recommendations for patients with renal impairment. Treatment is imperative for patients with severe, renal-associated extrahepatic manifestations of HCV infection. Aims We sought to describe the prevalence of these conditions among current HCV-infected patients in a population-based prospective, observational cohort study at four large US health systems. Methods Data from cohort patients with chronic HCV infection during 2012 were analyzed for the period from 2006–2013. We determined the prevalence of mild-moderately impaired renal function defined as having the most recent estimated glomerular filtration rate [eGFR] <80 ml/min/1.73m2, with severe impairment defined as eGFR<30 ml/min/1.73m2, based on the treatment guidelines. Prevalence of extrahepatic conditions were ascertained using ICD9-codes. Results Among 5,772 persons the prevalence of eGFR<80 was 33% and eGFR<30 was 2%, including among patients with hepatic fibrosis. Diagnosed extrahepatic renal manifestations were rare: vasculitis- 0.2%, nephrotic syndrome- 0.3%, and cryoglobulinemia- 0.9%. Conclusions While the prevalence of severe renal impairment and diagnosed extrahepatic manifestations were low, mild-to-moderate renal impairment was common in HCV patients, including those with advanced liver fibrosis for whom the need for treatment is urgent.
Subject:
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Adult
Aged
Article
Female
Glomerular Filtration Rate
Hepatic Fibrosis
Hepatitis C
Hepatitis C, Chronic
Humans
Male
Middle Aged
Prevalence
Renal Disease
Renal Insufficiency

Source:
Dig Dis Sci. 61(7):2087-2093.
Pubmed ID:
27216163
Pubmed Central ID:
PMC5675517
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States ;
CC999999/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:21502696a9699825629b14a421a0b3829b72d920c6b6552cb8e4199bac1e97c4
File Type:

Supporting Files

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