Characterization of Resistance Genes and Plasmids from Outbreaks and Illness Clusters Caused by Salmonella Resistant to Ceftriaxone in the United States, 2011–2012

Details

• Alternative Title:
  Microb Drug Resist
• Personal Author:
  Folster, Jason P. ; Grass, Julian E. ; Bicknese, Amelia ; Taylor, Julia ; Friedman, Cindy R. ; Whichard, Jean M.
• Description:
  Salmonella is an important cause of foodborne illness; however, quickly identifying the source of these infections can be difficult, and source identification is a crucial step in preventing additional illnesses. Although most infections are self-limited, invasive salmonellosis may require antimicrobial treatment. Ceftriaxone, an extended-spectrum cephalosporin, is commonly used for treatment of salmonellosis. Previous studies have identified a correlation between the food animal/retail meat source of ceftriaxone-resistant Salmonella and the type of resistance gene and plasmid it carries. In this study, we examined seven outbreaks of ceftriaxone-resistant Salmonella infections, caused by serotypes Typhimurium, Newport, Heidelberg, and Infantis. All isolates were positive for a plasmid-encoded bla|gene. Plasmid incompatibility typing identified five IncI1 and two IncA/C plasmids. Both outbreaks containing bla|-IncA/C plasmids were linked to consumption of cattle products. Three of five outbreaks with bla|-IncI1 (ST12) plasmids were linked to a poultry source. The remaining IncI1 outbreaks were associated with ground beef (ST20) and tomatoes (ST12). In addition, we examined isolates from five unsolved clusters of ceftriaxone-resistant Salmonella infections and used our plasmid-encoded gene findings to predict the source. Overall, we identified a likely association between the source of ceftriaxone-resistant Salmonella outbreaks and the type of resistance gene/plasmid it carries.
• Subjects:
  Animals Anti-Bacterial Agents Article Ceftriaxone Cephalosporins Disease Outbreaks DNA, Bacterial Drug Resistance, Bacterial Foodborne Diseases Meat Plasmids Salmonella Salmonella Infections

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• Source:
  Microb Drug Resist. 23(2):188-193.
• Pubmed ID:
  27828730
• Pubmed Central ID:
  PMC5656985
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  23
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:aa9dffabf75dc6c1125e5633a8e9661271a2f410382f8058f11761cc569c80fa
• Download URL:
  https://stacks.cdc.gov/view/cdc/49349/cdc_49349_DS1.pdf
• File Type:
  [PDF - 312.30 KB ]