Population structure of invasive Streptococcus pneumoniae isolates among Alaskan children in the conjugate vaccine era, 2001 to 2013☆,☆☆

Miernyk, Karen M.; Bulkow, Lisa R.; Case, Samantha L.; Zulz, Tammy; Bruce, Michael G.; Harker-Jones, Marcella; Hurlburt, Debby A.; Hennessy, Thomas W.; Rudolph, Karen M.

doi:10.1016/j.diagmicrobio.2016.07.004

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Population structure of invasive Streptococcus pneumoniae isolates among Alaskan children in the conjugate vaccine era, 2001 to 2013☆,☆☆

Published Date:

Jul 07 2016

Publisher's site:

http://dx.doi.org/10.1016/j.diagmicrobio.2016.07.004 New Site Icon

Source:

Diagn Microbiol Infect Dis. 86(2):224-230.

Language:

English

[PDF-658.57 KB]

Details:

Alternative Title:

Diagn Microbiol Infect Dis

Personal Author:

Miernyk, Karen M. ; Bulkow, Lisa R. ; Case, Samantha L. ; Zulz, Tammy ; Bruce, Michael G. ; ... More ▼

Description:

Here we describe the relationships between serotypes, genotypes, and antimicrobial susceptibility among isolates causing invasive pneumococcal disease in Alaskan children during the pneumococcal conjugate vaccine (PCV) era. From 2001 to 2013 we received 271 isolates representing 33 serotypes. The most common serotypes were 19A (29.5%, n= 80), 7F (12.5%, n= 34), 15B/C (6.3%, n= 17), and 22F (4.8%, n= 13). Multilocus sequence typing identified 11 clonal complexes (CC) and 45 singletons. Five CCs accounted for 52% (141/271) of the total: CC199 (21% [n= 57], serotypes 19A, 15B/C), CC191 (12.2% [n= 33], serotype 7F), CC172 (10.3% [n= 28], serotypes 19A, 23A, 23B), CC433 (4.4% [n= 12], serotype 22F), and CC100 (4.4% [n= 12], serotype 33F). The proportion of isolates nonsusceptible to erythromycin and tetracycline increased after 13-valent PCV use (14% [n= 30] versus 29% [n= 14]; P= 0.010) and (4% [n= 9] versus 22% [n= 11]; P< 0.001), respectively. The genetic diversity also increased after 13-valent PCV use (Simpson's diversity index =0.95 versus 0.91; P= 0.022).

Pubmed ID:

27498610

Pubmed Central ID:

PMC5649341

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Place as Subject:

Alaska

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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