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Population structure of invasive Streptococcus pneumoniae isolates among Alaskan children in the conjugate vaccine era, 2001 to 2013☆,☆☆
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Jul 07 2016
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Source: Diagn Microbiol Infect Dis 86(2):224-230
[PDF-658.57 KB]
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Alternative Title:Diagn Microbiol Infect Dis
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Description:Here we describe the relationships between serotypes, genotypes, and antimicrobial susceptibility among isolates causing invasive pneumococcal disease in Alaskan children during the pneumococcal conjugate vaccine (PCV) era From 2001 to 2013 we received 271 isolates representing 33 serotypes The most common serotypes were 19A (295%, n= 80), 7F (125%, n= 34), 15B/C (63%, n= 17), and 22F (48%, n= 13) Multilocus sequence typing identified 11 clonal complexes (CC) and 45 singletons Five CCs accounted for 52% (141/271) of the total: CC199 (21% [n= 57], serotypes 19A, 15B/C), CC191 (122% [n= 33], serotype 7F), CC172 (103% [n= 28], serotypes 19A, 23A, 23B), CC433 (44% [n= 12], serotype 22F), and CC100 (44% [n= 12], serotype 33F) The proportion of isolates nonsusceptible to erythromycin and tetracycline increased after 13-valent PCV use (14% [n= 30] versus 29% [n= 14]; P= 0010) and (4% [n= 9] versus 22% [n= 11]; P< 0001), respectively The genetic diversity also increased after 13-valent PCV use (Simpson's diversity index =095 versus 091; P= 0022)
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Pubmed ID:27498610
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Pubmed Central ID:PMC5649341
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Volume:86
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Issue:2
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