Details:

Alternative Title:
Diagn Microbiol Infect Dis
Publisher's site:
http://dx.doi.org/10.1016/j.diagmicrobio.2016.07.004
Personal Author:
Miernyk, Karen M. ; Bulkow, Lisa R. ; Case, Samantha L. ; Zulz, Tammy ; Bruce, Michael G. ; ... More +
Miernyk, Karen M. ; Bulkow, Lisa R. ; Case, Samantha L. ; Zulz, Tammy ; Bruce, Michael G. ; Harker-Jones, Marcella ; Hurlburt, Debby A. ; Hennessy, Thomas W. ; Rudolph, Karen M. Less -
Description:
Here we describe the relationships between serotypes, genotypes, and antimicrobial susceptibility among isolates causing invasive pneumococcal disease in Alaskan children during the pneumococcal conjugate vaccine (PCV) era. From 2001 to 2013 we received 271 isolates representing 33 serotypes. The most common serotypes were 19A (29.5%, n= 80), 7F (12.5%, n= 34), 15B/C (6.3%, n= 17), and 22F (4.8%, n= 13). Multilocus sequence typing identified 11 clonal complexes (CC) and 45 singletons. Five CCs accounted for 52% (141/271) of the total: CC199 (21% [n= 57], serotypes 19A, 15B/C), CC191 (12.2% [n= 33], serotype 7F), CC172 (10.3% [n= 28], serotypes 19A, 23A, 23B), CC433 (4.4% [n= 12], serotype 22F), and CC100 (4.4% [n= 12], serotype 33F). The proportion of isolates nonsusceptible to erythromycin and tetracycline increased after 13-valent PCV use (14% [n= 30] versus 29% [n= 14]; P= 0.010) and (4% [n= 9] versus 22% [n= 11]; P< 0.001), respectively. The genetic diversity also increased after 13-valent PCV use (Simpson's diversity index =0.95 versus 0.91; P= 0.022).
Subject:
[+]
Article
Child, Preschool
Genetic Variation
Genotype
Humans
Infant
Infant, Newborn
Multilocus Sequence Typing
Pneumococcal Infections
Serogroup
Streptococcal Vaccines

Source:
Diagn Microbiol Infect Dis. 86(2):224-230.
Pubmed ID:
27498610
Pubmed Central ID:
PMC5649341
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Alaska
Collection(s):
Arctic Investigations Program
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a36a99d75d6d41ce7509473fa6d5af08ea177267e29dfd2f8ea2cd372d575641
File Type:

Supporting Files

• 	nihms912713.nxml	xml
  	nihms912713f1.gif	gif
  	nihms912713f1.jpg	jpeg
  	nihms912713f2.gif	gif
  	nihms912713f2.jpg	jpeg
  	nihms912713f3.gif	gif
  	nihms912713f3.jpg	jpeg

More +