Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic White women

Martínez, María Elena; Gomez, Scarlett L.; Tao, Li; Cress, Rosemary; Rodriguez, Danielle; Unkart, Jonathan; Schwab, Richard; Nodora, Jesse N.; Cook, Linda; Komenaka, Ian; Li, Christopher

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Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic White women

Published Date:

Jul 11 2017

Source:

Breast Cancer Res Treat. 166(1):185-193.

Language:

English

[PDF-105.52 KB]

Details:

Personal Authors:

Martínez, María Elena ; Gomez, Scarlett L. ; Tao, Li ; Cress, Rosemary ; Rodriguez, Danielle ; ... More ▼

Keywords:

[+]

Pubmed ID:

28698973

Pubmed Central ID:

PMC5647237

Description:

Purpose

To assess tumor subtype distribution and the relative contribution of clinical and sociodemographic factors on breast cancer survival between Hispanic and non-Hispanic whites (NHW).

Methods

We analyzed data from the California Cancer Registry, which included 29,626 Hispanic and 99,862 NHW female invasive breast cancer cases diagnosed from 2004–2014. Logistic regression was used to assess ethnic differences in tumor subtype, and Cox proportional hazard modeling to assess differences in breast cancer survival.

Results

Hispanics compared to NHWs had higher odds of having triple negative (OR=1.29; 95% CI, 1.23–1.35) and HER2-overexpressing tumors (OR=1.19; 95% CI, 1.14–1.25 [HR−] and OR=1.39; 95% CI, 1.31–1.48 [HR+]). In adjusted models, Hispanic women had a higher risk of breast cancer mortality than NHW women (mortality rate ratio [MRR]=1.24; 95% CI, 1.19–1.28). Clinical factors accounted for most of the mortality difference (MRR=1.05; 95 % CI, 1.01–1.09); however, neighborhood socioeconomic status (SES) and health insurance together accounted for all of the mortality difference (MRR=1.01; 95% CI, 0.97–1.05).

Conclusions

Addressing SES disparities, including increasing access to health care, may be critical to overcoming poorer breast cancer outcomes in Hispanics.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

HHSN261201000140C/CA/NCI NIH HHS/United States
P30 CA118100/CA/NCI NIH HHS/United States
U54 CA132384/CA/NCI NIH HHS/United States
HHSN261201000035C/CA/NCI NIH HHS/United States
HHSN261201000035I/CA/NCI NIH HHS/United States
P30 CA023100/CA/NCI NIH HHS/United States
U54 CA132379/CA/NCI NIH HHS/United States
HHSN261201000034C/CA/NCI NIH HHS/United States
U58 DP003862/DP/NCCDPHP CDC HHS/United States

Main Document Checksum:

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Supporting Files:

nihms903992.nxml

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