Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic White women

Details

• Alternative Title:
  Breast Cancer Res Treat
• Personal Author:
  Martínez, María Elena ; Gomez, Scarlett L. ; Tao, Li ; Cress, Rosemary ; Rodriguez, Danielle ; Unkart, Jonathan ; Schwab, Richard ; Nodora, Jesse N. ; Cook, Linda ; Komenaka, Ian ; Li, Christopher
• Description:
  Purpose
  
  To assess tumor subtype distribution and the relative contribution of clinical and sociodemographic factors on breast cancer survival between Hispanic and non-Hispanic whites (NHW).
  
  Methods
  
  We analyzed data from the California Cancer Registry, which included 29,626 Hispanic and 99,862 NHW female invasive breast cancer cases diagnosed from 2004–2014. Logistic regression was used to assess ethnic differences in tumor subtype, and Cox proportional hazard modeling to assess differences in breast cancer survival.
  
  Results
  
  Hispanics compared to NHWs had higher odds of having triple negative (OR=1.29; 95% CI, 1.23–1.35) and HER2-overexpressing tumors (OR=1.19; 95% CI, 1.14–1.25 [HR−] and OR=1.39; 95% CI, 1.31–1.48 [HR+]). In adjusted models, Hispanic women had a higher risk of breast cancer mortality than NHW women (mortality rate ratio [MRR]=1.24; 95% CI, 1.19–1.28). Clinical factors accounted for most of the mortality difference (MRR=1.05; 95 % CI, 1.01–1.09); however, neighborhood socioeconomic status (SES) and health insurance together accounted for all of the mortality difference (MRR=1.01; 95% CI, 0.97–1.05).
  
  Conclusions
  
  Addressing SES disparities, including increasing access to health care, may be critical to overcoming poorer breast cancer outcomes in Hispanics.
  
  
• Subjects:
  Adult Aged Aged, 80 And Over Age Factors Biomarkers, Tumor Breast Neoplasms California Female Healthcare Disparities Hispanic Or Latino Humans Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Registries Socioeconomic Factors Tumor Burden White People Young Adult

  More +
• Keywords:
  Breast Cancer Disparities Health Insurance Hispanic Socioeconomic Factors
• Source:
  Breast Cancer Res Treat. 166(1):185-193
• Pubmed ID:
  28698973
• Pubmed Central ID:
  PMC5647237
• Document Type:
  Journal Article
• Funding:
  HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; P30 CA118100/CA/NCI NIH HHSUnited States/ ; U54 CA132384/CA/NCI NIH HHSUnited States/ ; P30 CA023100/CA/NCI NIH HHSUnited States/ ; U54 CA132379/CA/NCI NIH HHSUnited States/
• Volume:
  166
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:42bdf9230832dea7a4cbdfc441d34194f344732be67c359dae450e37c5c84ef0
• Download URL:
  https://stacks.cdc.gov/view/cdc/49240/cdc_49240_DS1.pdf
• File Type:
  [PDF - 105.52 KB ]