Aspirin Treatment Failure and the Risk of Recurrent Stroke and Death Among Patients with Ischemic Stroke

Georgiadis, Alexandros L.; Cordina, Steve M.; Vazquez, Gabriela; Tariq, Nauman; Suri, M. Fareed K.; Lakshminarayan, Kamakshi; Adams, Harold P.; Qureshi, Adnan I.

doi:10.1016/j.jstrokecerebrovasdis.2011.06.017

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Aspirin Treatment Failure and the Risk of Recurrent Stroke and Death Among Patients with Ischemic Stroke

Aug 10 2011
By Georgiadis, Alexandros L. ; Cordina, Steve M. ; Vazquez, Gabriela ; ...
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2011.06.017
Source: J Stroke Cerebrovasc Dis. 22(2):100-106.

[PDF-143.68 KB]

English

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Details:

Alternative Title:

J Stroke Cerebrovasc Dis
Personal Author:

Georgiadis, Alexandros L. ; Cordina, Steve M. ; Vazquez, Gabriela ; Tariq, Nauman ; Suri, M. Fareed K. ; ... More +

Georgiadis, Alexandros L. ; Cordina, Steve M. ; Vazquez, Gabriela ; Tariq, Nauman ; Suri, M. Fareed K. ; Lakshminarayan, Kamakshi ; Adams, Harold P. ; Qureshi, Adnan I. Less -
Description:

Background

The prognostic value of occurrence of ischemic stroke in a patient despite aspirin treatment (aspirin treatment failure) is not known. Our objective was to determine if aspirin treatment failure predicts recurrent ischemic stroke and/or death.

Methods

We performed a post-hoc analysis of data from the National Institute of Neurological Disorders and Stroke (NINDS) intravenous recombinant tissue plasminogen activator (rt-PA) trial and the Trial of ORG 10172 in Acute Stroke Treatment (TOAST). Multivariate analysis was used to calculate the odds ratio (OR) of recurrent stroke and recurrent stroke or death for aspirin treatment failure patients for the duration of available follow-up (3 months for TOAST patients; 12 months for NINDS rt-PA trial patients).

Results

The rate of aspirin treatment failure was 40% and 35% among 1275 patients and 624 patients recruited in the TOAST and NINDS rt-PA trials, respectively. The risk of stroke and death at 3 months and 1 year was not higher among patients classified as aspirin treatment failures among the TOAST (OR 1.1; 95% confidence interval [CI] 0.8–1.6; P =.7) or NINDS rt-PA trial patients (OR 0.8; 95% CI 0.6–1.3; P =.4), respectively. In subgroup analysis, aspirin treatment failure was not found to be associated with recurrent stroke or with the combined endpoint of stroke and death among categories defined by etiologic subtype, including those with large artery atherosclerosis.

Conclusions

In a post-hoc analysis of 2 randomized ischemic stroke trials, aspirin treatment failure was not found to be associated with an increased risk of recurrent stroke or death.
Subjects:

[+]

Aged Aspirin Brain Ischemia Female Humans Male Middle Aged Multivariate Analysis Odds Ratio Platelet Aggregation Inhibitors Predictive Value Of Tests Prognosis Randomized Controlled Trials As Topic Secondary Prevention Stroke Treatment Failure
Source:

J Stroke Cerebrovasc Dis. 22(2):100-106.
Pubmed ID:

21835634
Pubmed Central ID:

PMC5619691
Document Type:

Journal Article
Funding:

K23 NS051377/NS/NINDS NIH HHS/United States ; K23NS051377/NS/NINDS NIH HHS/United States ; U58DP000857/DP/NCCDPHP CDC HHS/United States ; R0-1-NS44976-01A2/NS/NINDS NIH HHS/United States ; R01 NS044976/NS/NINDS NIH HHS/United States ; ... More +

K23 NS051377/NS/NINDS NIH HHS/United States ; K23NS051377/NS/NINDS NIH HHS/United States ; U58DP000857/DP/NCCDPHP CDC HHS/United States ; R0-1-NS44976-01A2/NS/NINDS NIH HHS/United States ; R01 NS044976/NS/NINDS NIH HHS/United States ; U58 DP000857/DP/NCCDPHP CDC HHS/United States Less -
Volume:

22
Issue:

2
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:b196e86c2389113ba422370aaf7f5e0c1034f0a2c1d8fcc752d62f4a1ed1ea9a
Download URL:

https://stacks.cdc.gov/view/cdc/48444/cdc_48444_DS1.pdf
File Type:

	nihms907915.nxml	xml
	nihms907915f1.gif	gif
	nihms907915f1.jpg	jpeg

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