Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring

Details

• Alternative Title:
  Am J Epidemiol
• Personal Author:
  Stingone, Jeanette A. ; Luben, Thomas J. ; Carmichael, Suzan L. ; Aylsworth, Arthur S. ; Botto, Lorenzo D. ; Correa, Adolfo ; Gilboa, Suzanne M. ; Langlois, Peter H. ; Nembhard, Wendy N. ; Richmond-Bryant, Jennifer ; Shaw, Gary M. ; Olshan, Andrew F.
• Corporate Authors:
  for the National Birth Defects Prevention Study
• Description:
  Nutrients that regulate methylation processes may modify susceptibility to the effects of air pollutants. Data from the National Birth Defects Prevention Study (United States, 1997-2006) were used to estimate associations between maternal exposure to nitrogen dioxide (NO2), dietary intake of methyl nutrients, and the odds of congenital heart defects in offspring. NO2 concentrations, a marker of traffic-related air pollution, averaged across postconception weeks 2-8, were assigned to 6,160 nondiabetic mothers of cases and controls using inverse distance-squared weighting of air monitors within 50 km of maternal residences. Intakes of choline, folate, methionine, and vitamins B6 and B12 were assessed using a food frequency questionnaire. Hierarchical regression models, which accounted for similarities across defects, were constructed, and relative excess risks due to interaction were calculated. Relative to women with the lowest NO2 exposure and high methionine intake, women with the highest NO2 exposure and lowest methionine intake had the greatest odds of offspring with a perimembranous ventricular septal defect (odds ratio = 3.23, 95% confidence interval: 1.74, 6.01; relative excess risk due to interaction = 2.15, 95% confidence interval: 0.39, 3.92). Considerable departure from additivity was not observed for other defects. These results provide modest evidence of interaction between nutrition and NO2 exposure during pregnancy.
• Subjects:
  Adult Air Pollutants Air Pollution Case-Control Studies Choline Diet Records Eating Female Folic Acid Food Analysis Heart Defects, Congenital Humans Infant, Newborn Maternal Exposure Methionine Nitrogen Dioxide Odds Ratio Pregnancy Prenatal Nutritional Physiological Phenomena Risk Factors United States Vitamin B 6 Vitamin B 12

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• Keywords:
  Air Pollution Birth Defects Cardiovascular Malformation Methionine Methyl Donor Prenatal Nutrition Ventricular Septal Defect
• Source:
  Am J Epidemiol. 186(6):719-729
• Pubmed ID:
  28520847
• Pubmed Central ID:
  PMC5610640
• Document Type:
  Journal Article
• Funding:
  P30 ES010126/ES/NIEHS NIH HHSUnited States/ ; U01 DD000491/DD/NCBDD CDC HHSUnited States/ ; U01 DD001229/DD/NCBDD CDC HHSUnited States/ ; T32 ES007018/ES/NIEHS NIH HHSUnited States/ ; U01 DD001036/DD/NCBDD CDC HHSUnited States/ ; U01 DD001285/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; P2C HD050924/HD/NICHD NIH HHSUnited States/
• Volume:
  186
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:65250f5c534a26bce6dd8de2eec22014b50dd4771177af4ed25ffad9bc76aa19ea46472ee21e014bd25f52b2a880cbc5725b907399af245fbd6d0718ac657125
• Download URL:
  https://stacks.cdc.gov/view/cdc/48254/cdc_48254_DS1.pdf
• File Type:
  [PDF - 252.14 KB ]