Details:

Alternative Title:
Regul Toxicol Pharmacol
Publisher's site:
http://dx.doi.org/10.1016/j.yrtph.2012.06.008
Personal Author:
Pohl, Hana R. ; Ruiz, Patricia ; Scinicariello, Franco ; Mumtaz, Moiz M.
Pohl, Hana R. ; Ruiz, Patricia ; Scinicariello, Franco ; Mumtaz, Moiz M. Less -
Description:
Exposure to chemicals occurs often as mixtures. Presented in this paper is information on alkoxyethanols and the impact they might have on human health in combination with some commonly found aliphatic and aromatic compounds. Our studies to evaluate the joint toxicity of these chemicals among themselves and in combination with other chemicals reveal a variety of possible outcomes depending on the exposure scenario. The interactions are predominantly based on metabolic pathways and are common among several solvents and organic compounds. Quantitative structure activity relationship (QSAR) analysis can be used with high confidence to identify chemicals that will interact to influence overall joint toxicity. Potential human exposure to a combination of alkoxyethanol, toluene and substituted benzenes may increase reproductive and developmental disease conditions. Inheritable gene alterations result in changes in the enzyme function in different subpopulations causing variations in quantity and/or quality of particular isoenzymes. These changes are responsible for differential metabolism of chemicals in species, genders, and life stages and are often the basis of a population's susceptibility. Unique genotypes introduced as a function of migration can alter the genetic makeup of any given population. Hence special consideration should be given to susceptible populations while conducting chemical health risk assessments.
Subject:
[+]
Alcohol Dehydrogenase
Alcohols
Aldehyde Dehydrogenase
Alkoxyethanols
Animals
Article
Computer Simulation
Drug Interactions
Female
Gene Expression
Genetic Variability
Humans
Male
Mixtures Toxicity
QSAR Modeling
Quantitative Structure-Activity Relationship
Risk Assessment
Solvents
Species Specificity
Toxicity Tests

Source:
Regul Toxicol Pharmacol. 64(1):134-142.
Pubmed ID:
22749914
Pubmed Central ID:
PMC5599109
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:91b4921a4db52ee9512f6f5411ea84c4e548bf706b29b655596b5b9c894cc53e
File Type:

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