Details:

Alternative Title:
Regul Toxicol Pharmacol
Personal Author:
Ingber, Susan Z. ; Pohl, Hana R.
Ingber, Susan Z. ; Pohl, Hana R. Less -
Description:
Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8-17 [rats], GD 12-14 and PND 3-10 [mice]) and motor function performance (insufficient data for rats, GD 12-17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review.
Subjects:
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Age Factors Animals Animals, Newborn Article Behavior, Animal Central Nervous System Chemical Exposures Dose-Response Relationship, Drug Environmental Pollutants Female Gestational Age Humans Laboratory Animals Mice Models, Animal Morphogenesis Motor Activity Motor Development Motor Neurons Neurotoxicity Syndromes Pregnancy Prenatal Exposure Delayed Effects Rats Risk Assessment Species Specificity Time Factors Toxicity Tests Windows Of Sensitivity
Source:
Regul Toxicol Pharmacol. 74:93-104.
Pubmed ID:
26686904
Pubmed Central ID:
PMC5599107
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c3ddc18a65c026b40e687fd779e321e38b30c3e6619d4344c12ecb77f2b01c11
Download URL:
https://stacks.cdc.gov/view/cdc/48209/cdc_48209_DS1.pdf
File Type:

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