Details:

Alternative Title:
Regul Toxicol Pharmacol
Publisher's site:
http://dx.doi.org/10.1016/j.yrtph.2015.11.018
Personal Author:
Ingber, Susan Z. ; Pohl, Hana R.
Ingber, Susan Z. ; Pohl, Hana R. Less -
Description:
Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8-17 [rats], GD 12-14 and PND 3-10 [mice]) and motor function performance (insufficient data for rats, GD 12-17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review.
Subject:
[+]
Age Factors
Animals
Animals, Newborn
Article
Behavior, Animal
Central Nervous System
Chemical Exposures
Dose-Response Relationship, Drug
Environmental Pollutants
Female
Gestational Age
Humans
Laboratory Animals
Mice
Models, Animal
Morphogenesis
Motor Activity
Motor Development
Motor Neurons
Neurotoxicity Syndromes
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Risk Assessment
Species Specificity
Time Factors
Toxicity Tests
Windows Of Sensitivity

Source:
Regul Toxicol Pharmacol. 74:93-104.
Pubmed ID:
26686904
Pubmed Central ID:
PMC5599107
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c3ddc18a65c026b40e687fd779e321e38b30c3e6619d4344c12ecb77f2b01c11
File Type:

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