Surveillance of high-grade cervical cancer precursors (CIN III/AIS) in four population-based cancer registries, United States, 2009–2012

Watson, Meg; Soman, Ashwini; Flagg, Elaine W.; Unger, Elizabeth; Deapen, Dennis; Chen, Vivien W.; Peres, Lauren C.; Copeland, Glenn; Tucker, Thomas C.; Garnett, Erin; Saraiya, Mona

doi:10.1016/j.ypmed.2017.07.027

i

Surveillance of high-grade cervical cancer precursors (CIN III/AIS) in four population-based cancer registries, United States, 2009–2012

Supporting Files

Jul 29 2017
By Watson, Meg ; Soman, Ashwini ; Flagg, Elaine W. ; ...

File Language:

English

Details

Alternative Title:

Prev Med
Personal Author:

Watson, Meg ; Soman, Ashwini ; Flagg, Elaine W. ; Unger, Elizabeth ; Deapen, Dennis ; Chen, Vivien W. ; Peres, Lauren C. ; Copeland, Glenn ; Tucker, Thomas C. ; Garnett, Erin ; Saraiya, Mona
Description:

Surveillance of cervical intraepithelial neoplasia grade III (CIN III) and adenocarcinoma in situ (AIS) is important for determining the burden of a preventable disease, identifying effects of vaccination on future diagnoses, and developing targeted programs. We analyzed population-based rates of high-grade cervical cancer precursor lesions using data from four central cancer registries (diagnosis years 2009-2012 from Louisiana, Kentucky, Michigan, and diagnosis years 2011-2012 from Los Angeles) by age, race, and histology. We also compared rates of precursors to invasive cancers. With 4 complete years of data from Michigan, we were able to conduct a trend analysis for that state. Data analysis was conducted in Atlanta during 2016. Kentucky reported the highest rate of CIN III/AIS (69.8), followed by Michigan (55.4), Louisiana (42.3), and Los Angeles (19.2). CIN III/AIS rates declined among women in Michigan by 37% each year for women aged 15-19, 14% for those aged 20-24, and 7% for those aged 25-29. Rates of CIN III/AIS vary by registry, and were higher than invasive cancer. In Michigan, declines in CIN III/AIS among women aged 15-29 are likely related in part to updated screening recommendations, and to the impact of human papillomavirus vaccination.
Subjects:

Adolescent Adult Cervical Intraepithelial Neoplasia Female Humans Mass Screening Middle Aged Papillomavirus Infections Population Surveillance Registries Uterine Cervical Neoplasms Vaccination Young Adult
Source:

Prev Med. 103:60-65.
Pubmed ID:

28765084
Pubmed Central ID:

PMC5591775
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Volume:

103
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:67c4262c7741da2ef0d1bae198c19bb8cc70abbeeb77d48746d562adf8f50ebf
Download URL:

https://stacks.cdc.gov/view/cdc/48044/cdc_48044_DS1.pdf
File Type:

[PDF - 283.12 KB ]

File Language:

English

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