First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Dörnemann, Jenny ; Burzio, Chiara ; Ronsse, Axelle ; Sprecher, Armand ; De Clerck, Hilde ; Van Herp, Michel ; Kolié, Marie-Claire ; Yosifiva, Vesselina ; Caluwaerts, Severine ; McElroy, Anita K. ; Antierens, Annick
• Description:
  A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.
• Subjects:
  Alanine Antibodies, Monoclonal Antiviral Agents Blood Female Hemorrhagic Fever, Ebola Humans Immunologic Factors Infant, Newborn Pregnancy Ribonucleotides Therapies, Investigational Treatment Outcome Young Adult

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• Source:
  J Infect Dis. 215(2):171-174.
• Pubmed ID:
  28073857
• Pubmed Central ID:
  PMC5583641
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  215
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b3e7b03c5b757eaa189f2fdb07f48f430190ef7eee7551f9570f379b1931cdc0
• Download URL:
  https://stacks.cdc.gov/view/cdc/48011/cdc_48011_DS1.pdf
• File Type:
  [PDF - 99.30 KB ]