NIOSH Skin Notation (SK) Profile: 2-hydroxypropyl acrylate (HPA) [CAS No. 999-61-1]

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  No studies that evaluated the dermal absorption of HPA were identified in humans or animals. However, acute toxicity data [Smyth et al. 1969] suggest that HPA is dermally absorbed, systemically available, and potentially fatal. Occupational case reports [Lovell et al. 1985; Kanerva et al. 1988] and animal data [Smyth et al. 1969; BP Chemicals, Inc. 1981] demonstrate that HPA is an irritant and corrosive to the skin. Human patch tests [Lovell et al. 1985; Kanerva et al. 1988, 1992a, b] and guinea pig maximization tests [Clemmensen 1984] sufficiently demonstrate the skin sensitization potential of HPA. Therefore, on the basis of these assessments, HPA is assigned a composite skin notation of SK: SYS (FATAL)-DIR (COR)-SEN. Table 3 summarizes the skin hazard designations for HPA previously issued by NIOSH and other organizations. The equivalent dermal designations for HPA, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals, are Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin), Skin Corrosion Category 1B (Hazard statement: Causes severe skin burns and eye damage) and Skin Sensitization Category 1 (Hazard statement: May cause an allergic skin reaction) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Corrosion Epidemiology Hazardous Substances Hypersensitivity Laboratories Mortality Occupational Health Risk Assessment Risk Factors Safety Skin Skin Diseases Toxicology

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• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute toxicity; Laboratory testing; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Dermal-exposure; Exposure assessment; In vivo studies; Dermal absorption; Skin irritants; In vitro studies; Lethal dose; Humans; Systematic reviews; GHS; Globally Harmonized System of Classification and Labeling of Chemicals; 2-Hydroxypropyl acrylate; Skin sensitivity; Sensitizers; Case reports; Fatalities; Corrosives; Toxic effects; Toxic materials; Hazardous materials; Allergic dermatitis; Allergic reactions; Carcinogenicity
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-188, 2017 Aug; :1-8
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2017188
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20050231
• NTIS Accession Number:
  PB2018-100171
• CAS Registry Number:
  2-Hydroxypropyl acrylate (CAS RN 999-61-1)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5d4028d804a841fab0d7713b7e19ffbc984a06c992680b03df6388bf1520bec9b4887b621765056e53809443a3bddce2f5729a6821b6836779b0cb868657150a
• Download URL:
  https://stacks.cdc.gov/view/cdc/47713/cdc_47713_DS1.pdf
• File Type:
  [PDF - 226.27 KB ]