NIOSH skin notation (SK) profile : 2-hydroxypropyl acrylate (HPA) [CAS No. 999-61-1]
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NIOSH skin notation (SK) profile : 2-hydroxypropyl acrylate (HPA) [CAS No. 999-61-1]

  • Published Date:

    August 2017

  • Series:
    DHHS publication ; no. (NIOSH) 2017-188
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  • Description:
    "No studies that evaluated the dermal absorption of HPA were identified in humans or animals. However, acute toxicity data [Smyth et al. 1969] suggest that HPA is dermally absorbed, systemically available, and potentially fatal. Occupational case reports [Lovell et al. 1985; Kanerva et al. 1988] and animal data [Smyth et al. 1969; BP Chemicals, Inc. 1981] demonstrate that HPA is an irritant and corrosive to the skin. Human patch tests [Lovell et al. 1985; Kanerva et al. 1988, 1992a, b] and guinea pig maximization tests [Clemmensen 1984] sufficiently demonstrate the skin sensitization potential of HPA. Therefore, on the basis of these assessments, HPA is assigned a composite skin notation of SK: SYS (FATAL)-DIR (COR)-SEN. Table 3 summarizes the skin hazard designations for HPA previously issued by NIOSH and other organizations. The equivalent dermal designations for HPA, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals, are Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin), Skin Corrosion Category 1B (Hazard statement: Causes severe skin burns and eye damage) and Skin Sensitization Category 1 (Hazard statement: May cause an allergic skin reaction) [European Parliament 2008]." - NIOSHTIC-2 Suggested citation: NIOSH [2017]. NIOSH [2017]. NIOSH skin notation profile: 2-Hydroxypropyl acrylate. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-188. NIOSHTIC no. 20050231
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