Details:

Alternative Title:
Sci Rep
Personal Author:
Schuh, Amy J. ; Amman, Brian R. ; Sealy, Tara K. ; Spengler, Jessica R. ; Nichol, Stuart T. ; ... More +
Schuh, Amy J. ; Amman, Brian R. ; Sealy, Tara K. ; Spengler, Jessica R. ; Nichol, Stuart T. ; Towner, Jonathan S. Less -
Description:
Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature. The Egyptian rousette bat (ERB) is a known reservoir host for Marburg virus (MARV). Following infection of ERBs with MARV, virus-specific IgG antibodies are induced but rapidly wane and by 3 months post-infection the bats are seronegative. To determine whether reinfection of ERBs plays a role in MARV maintenance, we challenge groups of ERBs that were "naturally" or experimentally infected with MARV 17-24 months prior. No bats in either group exhibit evidence of MARV replication or shedding and all bats develop virus-specific secondary immune responses. This study demonstrates that infection of ERBs with MARV induces long-term protective immunity against reinfection and indicates that other factors, such as host population dynamics, drive MARV maintenance in nature.
Subject:
[+]
Animals Antibodies, Viral Antibody Specificity Chiroptera Host-Pathogen Interactions Immunity Immunoglobulin G Marburgvirus Marburg Virus Disease Virus Replication
Source:
Sci Rep. 7.
Pubmed ID:
28821722
Pubmed Central ID:
PMC5562751
Document Type:
Journal Article
Place as Subject:
Egypt
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e327db3ab52961deabdfdf6e8c06eef7040d3006e5796bf1e956d99d0e501fe9
Download URL:
https://stacks.cdc.gov/view/cdc/47692/cdc_47692_DS1.pdf
File Type:

Supporting Files

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