Welcome to CDC stacks | NIOSH skin notation (SK) profile : 1-Bromopropane [CAS No. 106-94-5]. - 47680 | Stephen B. Thacker CDC Library collection
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
NIOSH skin notation (SK) profile : 1-Bromopropane [CAS No. 106-94-5].
  • Published Date:
    August 2017
  • Series:
    DHHS publication ; no. (NIOSH) 2017-187
  • Language:
    English
Filetype[PDF-280.20 KB]


Details:
  • Description:
    "The mathematical model predicted that 1-BP was absorbed by the skin. Additionally, there was an in vitro dermal penetration study identified that indicates that 1-BP has the potential for substantial dermal penetration dependent on type and duration of exposure [Frasch et al. 2011]. A review of the available literature indicates that 1-BP is capable of inducing a wide array of adverse systemic health effects, including neurotoxicity, hepatotoxicity, hematotoxicity, reproductive toxicity, and developmental toxicity, regardless of exposure route [ClinTrials Bioresearch 1997; Zhao et al. 1999; Ichihara et al. 2000a, 2000b; WIL Research Laboratory 2001; Wang et al. 2002, 2003; Lee et al. 2005, 2007; Banu et al. 2007; Fueta et al. 2007]. Although the exact systemic hazards associated with skin contact and absorption of 1-BP are unknown, 1-BP is assigned the SK: SYS notation; this notation is based on the recognition of adverse health effects in test animals exposed via the inhalation, oral, and subcutaneous injection routes. Although a study using the EpiDerm human reconstructed epidermis model [Frasch et al. 2011] indicated that 1-BP is not corrosive to the skin following exposure to 1-BP, two in vivo tests, conducted with standard methods [Jacobs et al. 1987; Pálovics 2004], provide sufficient evidence that 1-BP is irritating to the skin of rabbits. Although no human patch tests that evaluated the sensitization potential of 1-BP were identified, one guinea pig maximization test [Elf Atochem 1995b] showed that the substance is not a skin sensitizer. Therefore, on the basis of this assessment, 1-BP is assigned the composite skin notation SK: SYS-DIR (IRR). Table 3 summarizes the skin designations for 1-BP from NIOSH and other organizations. The equivalent skin designation for 1-BP from the Globally Harmonized System (GHS) of Classification and Labelling is Reproductive Category 1B (Presumed human reproductive toxicant) and Skin Irritation Category 2 (Causes skin irritation) [European Parliament 2008]." - NIOSHTIC-2

    Suggested citation: NIOSH [2017]. NIOSH skin notation profile: 1-Bromopropane. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publi- cation No. 2017-187.

    NIOSHTIC no. 20050228

  • Main Document Checksum:
  • Supporting Files:
    No Additional Files
No Related Documents.
You May Also Like: