i
NIOSH skin notation (SK) profile : 1-Bromopropane [CAS No. 106-94-5].
-
August 2017
[PDF-280.20 KB]
Details:
-
Personal Author:
-
Corporate Authors:
-
Description:"The mathematical model predicted that 1-BP was absorbed by the skin. Additionally, there was an in vitro dermal penetration study identified that indicates that 1-BP has the potential for substantial dermal penetration dependent on type and duration of exposure [Frasch et al. 2011]. A review of the available literature indicates that 1-BP is capable of inducing a wide array of adverse systemic health effects, including neurotoxicity, hepatotoxicity, hematotoxicity, reproductive toxicity, and developmental toxicity, regardless of exposure route [ClinTrials Bioresearch 1997; Zhao et al. 1999; Ichihara et al. 2000a, 2000b; WIL Research Laboratory 2001; Wang et al. 2002, 2003; Lee et al. 2005, 2007; Banu et al. 2007; Fueta et al. 2007]. Although the exact systemic hazards associated with skin contact and absorption of 1-BP are unknown, 1-BP is assigned the SK: SYS notation; this notation is based on the recognition of adverse health effects in test animals exposed via the inhalation, oral, and subcutaneous injection routes. Although a study using the EpiDerm human reconstructed epidermis model [Frasch et al. 2011] indicated that 1-BP is not corrosive to the skin following exposure to 1-BP, two in vivo tests, conducted with standard methods [Jacobs et al. 1987; Pálovics 2004], provide sufficient evidence that 1-BP is irritating to the skin of rabbits. Although no human patch tests that evaluated the sensitization potential of 1-BP were identified, one guinea pig maximization test [Elf Atochem 1995b] showed that the substance is not a skin sensitizer. Therefore, on the basis of this assessment, 1-BP is assigned the composite skin notation SK: SYS-DIR (IRR). Table 3 summarizes the skin designations for 1-BP from NIOSH and other organizations. The equivalent skin designation for 1-BP from the Globally Harmonized System (GHS) of Classification and Labelling is Reproductive Category 1B (Presumed human reproductive toxicant) and Skin Irritation Category 2 (Causes skin irritation) [European Parliament 2008]." - NIOSHTIC-2
Suggested citation: NIOSH [2017]. NIOSH skin notation profile: 1-Bromopropane. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publi- cation No. 2017-187.
NIOSHTIC no. 20050228
-
Subjects:
-
Series:
-
Document Type:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
