NIOSH Skin Notation (SK) Profile: 1-Bromopropane [CAS No. 106-94-5]

Details

• Personal Author:
  Dotson, G. Scott ; Hudson, Naomi L.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  "The mathematical model predicted that 1-BP was absorbed by the skin. Additionally, there was an in vitro dermal penetration study identified that indicates that 1-BP has the potential for substantial dermal penetration dependent on type and duration of exposure [Frasch et al. 2011]. A review of the available literature indicates that 1-BP is capable of inducing a wide array of adverse systemic health effects, including neurotoxicity, hepatotoxicity, hematotoxicity, reproductive toxicity, and developmental toxicity, regardless of exposure route [ClinTrials Bioresearch 1997
  
  Zhao et al. 1999
  
  Ichihara et al. 2000a, 2000b
  
  WIL Research Laboratory 2001
  
  Wang et al. 2002, 2003
  
  Lee et al. 2005, 2007
  
  Banu et al. 2007
  
  Fueta et al. 2007]. Although the exact systemic hazards associated with skin contact and absorption of 1-BP are unknown, 1-BP is assigned the SK: SYS notation
  
  this notation is based on the recognition of adverse health effects in test animals exposed via the inhalation, oral, and subcutaneous injection routes. Although a study using the EpiDerm human reconstructed epidermis model [Frasch et al. 2011] indicated that 1-BP is not corrosive to the skin following exposure to 1-BP, two in vivo tests, conducted with standard methods [Jacobs et al. 1987
  
  Pálovics 2004], provide sufficient evidence that 1-BP is irritating to the skin of rabbits. Although no human patch tests that evaluated the sensitization potential of 1-BP were identified, one guinea pig maximization test [Elf Atochem 1995b] showed that the substance is not a skin sensitizer. Therefore, on the basis of this assessment, 1-BP is assigned the composite skin notation SK: SYS-DIR (IRR). Table 3 summarizes the skin designations for 1-BP from NIOSH and other organizations. The equivalent skin designation for 1-BP from the Globally Harmonized System (GHS) of Classification and Labelling is Reproductive Category 1B (Presumed human reproductive toxicant) and Skin Irritation Category 2 (Causes skin irritation) [European Parliament 2008]." - NIOSHTIC-2
  
  Suggested citation: NIOSH [2017]. NIOSH skin notation profile: 1-Bromopropane. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publi- cation No. 2017-187.
  
  NIOSHTIC no. 20050228
  
  
• Subjects:
  Occupational Health Safety
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2017187
• Document Type:
  Text
• Genre:
  Pamphlet (or booklet)
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11 numbered pages
• NIOSHTIC Number:
  nn:20050228
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2bc236fe60a5d892b42770512634d8092594477c78afea7f1535cf28a72f5b5cbf3e0a8b53b227133c7f9391bdd9237beabd3bad6f22d87ba7309ef222daf4b5
• Download URL:
  https://stacks.cdc.gov/view/cdc/47680/cdc_47680_DS1.pdf
• File Type:
  [PDF - 280.20 KB ]