NIOSH skin notation (SK) profile: Heptachlor [CAS No. 76-44-8]
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NIOSH skin notation (SK) profile: Heptachlor [CAS No. 76-44-8]

  • Published Date:

    August 2017

  • Series:
    DHHS publication ; no. (NIOSH) 2017-186
  • Language:
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  • Description:
    "No quantitative data on the dermal absorption kinetics of heptachlor were identified. A mathematical model predicted heptachlor is not likely to be absorbed through the skin. However, acute toxicity studies in rats [Gaines 1960, 1969] showed that the chemical has the potential to be absorbed through the skin, systemically available, and toxic following acute dermal exposure. No studies were identified that evaluated the potential of heptachlor to be corrosive or irritating to the skin or be a skin sensitizer. A structure- activity relationship model predicted heptachlor to be negative for skin irritation, but a plausible skin sensitizer. Skin sensitization potential predicted by the model highlights testing for this endpoint as an important data gap. Therefore, on the basis of these assessments, heptachlor is assigned a composite skin notation of SK: SYS. Table 3 summarizes the skin hazard designations for heptachlor previously issued by NIOSH and other organizations. The equivalent dermal designation for heptachlor, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008]." - NIOSHTIC-2 Suggested citation: NIOSH [2017]. NIOSH skin notation profile: Heptachlor. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-186.. NIOSHTIC no. 20050227
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