NIOSH Skin Notation (SK) Profile: Disulfoton [CAS No. 298-04-4]

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  The available data in both humans and animals indicate that disulfoton is absorbed through skin, is systemically available, acutely toxic and potentially fatal following acute dermal exposure Gaines 1969; Bayer AG 1978, and can cause cholinesterase inhibition following prolonged exposure to the skin Savage 1971; Wolfe et al. 1978. Insufficient data precludes the assessment of skin irritation and sensitization potential of disulfoton. Therefore, on the basis of these assessments, disulfoton is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for disulfoton previously issued by NIOSH and other organizations. The equivalent dermal designations for disulfoton, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) European Parliament 2008. Description provided by NIOSH
• Subjects:
  • Animals
  • Carcinogens
  • Epidemiology
  • Hazardous Substances
  • Laboratories
  • Mortality
  • Occupational Health
  • Poisoning
  • Risk Assessment
  • Risk Factors
  More +
• Keywords:
  • Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute toxicity; Laboratory testing; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Dermal-exposure; Exposure assessment; In vivo studies; Dermal absorption; In vitro studies; Lethal dose; Humans; Systematic reviews; Toxic dose; Disulfoton; Fatalities; Toxic effects; Toxic materials; Poisons; GHS; Globally Harmonized System of Classification and Labeling of Chemicals; Carcinogenicity
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-185, 2017 Aug; :1-9
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2017185
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20050226
• NTIS Accession Number:
  PB2018-100168
• CAS Registry Number:
  • Disulfoton (CAS RN 298-04-4)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/47623/cdc_47623_DS1.pdf
• File Type:
  [PDF - 226.54 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:66add2936d88ad18c5231bdd8cd77371be11616f629984a84ecd88603e7eb973fb9542f05fc780a71730e060833c892350f869a43d09ee4c26fcfddc41332a3e