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NIOSH skin notation (SK) profile: Disulfoton [CAS No. 298-04-4]
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August 2017
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Description:"The available data in both humans and animals indicate that disulfoton is absorbed through skin, is systemically available, acutely toxic and potentially fatal following acute dermal exposure [Gaines 1969; Bayer AG 1978], and can cause cholinesterase inhibition following prolonged exposure to the skin [Savage 1971; Wolfe et al. 1978]. Insufficient data precludes the assessment of skin irritation and sensitization potential of disulfoton. Therefore, on the basis of these assessments, disulfoton is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for disulfoton previously issued by NIOSH and other organizations. The equivalent dermal designations for disulfoton, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) [European Parliament 2008]." - NIOSHTIC-2
Suggested citation: NIOSH [2017]. NIOSH skin notation profile: Disulfoton. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-185.
NIOSHTIC no. 20050226
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