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Nuclear bodies: The emerging biophysics of nucleoplasmic phases
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May 15 2015
Source: Curr Opin Cell Biol. 34:23-30. -
Alternative Title:Curr Opin Cell Biol
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Description:The cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work suggests that low complexity/disordered protein motifs and repetitive binding domains drive assembly of droplets of nuclear RNA/protein by promoting nucleoplasmic phase separation. Nucleation and maturation of these structures is regulated by, and may in turn affect, factors including post-translational modifications, protein concentration, transcriptional activity, and chromatin state. Here we present a concise review of these exciting recent advances, and discuss current and future challenges in understanding the assembly, regulation, and function of nuclear RNA/protein bodies.
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Pubmed ID:25942753
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Pubmed Central ID:PMC5562147
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