Nuclear bodies: The emerging biophysics of nucleoplasmic phases

Details

• Alternative Title:
  Curr Opin Cell Biol
• Personal Author:
  Zhu, Lian ; Brangwynne, Clifford P.
• Description:
  The cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work suggests that low complexity/disordered protein motifs and repetitive binding domains drive assembly of droplets of nuclear RNA/protein by promoting nucleoplasmic phase separation. Nucleation and maturation of these structures is regulated by, and may in turn affect, factors including post-translational modifications, protein concentration, transcriptional activity, and chromatin state. Here we present a concise review of these exciting recent advances, and discuss current and future challenges in understanding the assembly, regulation, and function of nuclear RNA/protein bodies.
• Subjects:
  Animals Article Biophysical Phenomena Cell Nucleus Chromatin Humans Intranuclear Inclusion Bodies Nuclear Proteins Protein Processing, Post-Translational
• Source:
  Curr Opin Cell Biol. 34:23-30.
• Pubmed ID:
  25942753
• Pubmed Central ID:
  PMC5562147
• Document Type:
  Journal Article
• Funding:
  DP2 GM105437/GM/NIGMS NIH HHS/United States ; 1DP2GM105437-01/DP/NCCDPHP CDC HHS/United States
• Volume:
  34
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:aa3f8104b15c56195e55f128dfe63f8d15fd7dbdab6a3c8751faf6adc0bd6a35
• Download URL:
  https://stacks.cdc.gov/view/cdc/47613/cdc_47613_DS1.pdf
• File Type:
  [PDF - 334.14 KB ]