Biology of Coccidioimycosis
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Biology of Coccidioimycosis

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    In the environment, Coccioides spp. exists as a mold (1) with septate hyphae. The hyphae fragment into arthroconidia (2), which measure only 2-4 μm in diameter and are easily aerosolized when disturbed (3). Arthroconidia are inhaled by a susceptible host (4) and settle into the lungs. The new environment signals a morphologic change, and the arthroconidia become spherules (5). Spherules divide internally until they are filled with endospores (6). When a spherule ruptures (7) the endospores are released and disseminate within surrounding tissue. Endospores are then able to develop into new spherules (6) and repeat the cycle. Publication date from document properties. coccidiomycosis-lifecycle508c.pdf
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