Details:

Alternative Title:
Trop Med Health
Publisher's site:
http://dx.doi.org/10.1186/s41182-017-0063-8
Personal Author:
Coutts, Shaun P. ; King, Jonathan D. ; Pa’au, Molisamoa ; Fuimaono, Saipale ; Roth, Joseph ; ... More +
Coutts, Shaun P. ; King, Jonathan D. ; Pa’au, Molisamoa ; Fuimaono, Saipale ; Roth, Joseph ; King, Mary Rose ; Lammie, Patrick J. ; Lau, Colleen L. ; Graves, Patricia M. Less -
Description:
Background

In 2000, American Samoa had 16.5% prevalence of lymphatic filariasis (LF) antigenemia. Annual mass drug administration (MDA) was conducted using single-dose albendazole plus diethylcarbamazine from 2000 to 2006. This study presents the results of a 2007 population-based PacELF C-survey in all ages and compares the adult filarial antigenemia results of this survey to those of a subsequent 2010 survey in adults with the aim of improving understanding of LF transmission after MDA.

Results

The 2007 C-survey used simple random sampling of households from a geolocated list. In 2007, the overall LF antigen prevalence by immunochromatographic card test (ICT) for all ages was 2.29% (95% CI 1.66–3.07). Microfilaremia prevalence was 0.27% (95% CI 0.09–0.62). Increasing age (OR 1.04 per year, 95% CI 1.02–1.05) was significantly associated with ICT positivity on multivariate analysis, while having ever taking MDA was protective (OR 0.39, 95% CI 0.16–0.96). The 2010 survey used a similar spatial sampling design.

Conclusions

After 7 years of MDA, with four rounds achieving effective coverage, a representative household survey in 2007 showed a decline in prevalence from 16.5 to 2.3% in all ages. However, lack of further decline in adult prevalence by 2010 and fluctuation at the village level showed that overall antigenemia prevalence at a broader scale may not provide an accurate reflection of ongoing transmission at the village level.


Subject:
[+]
American Samoa
Epidemiology
Lymphatic Filariasis
MDA
PacELF
Prevalence
Research
Wuchereria Bancrofti

Source:
Trop Med Health. 45.
Pubmed ID:
28794687
Pubmed Central ID:
PMC5543440
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f3f7c26263d8621142ec63db739c4c2289c4f5593d8b9ff6ebc90473a21676ad
File Type:

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