Prevalence and risk factors associated with lymphatic filariasis in American Samoa after mass drug administration

Details

• Alternative Title:
  Trop Med Health
• Personal Author:
  Coutts, Shaun P. ; King, Jonathan D. ; Pa’au, Molisamoa ; Fuimaono, Saipale ; Roth, Joseph ; King, Mary Rose ; Lammie, Patrick J. ; Lau, Colleen L. ; Graves, Patricia M.
• Description:
  Background
  
  In 2000, American Samoa had 16.5% prevalence of lymphatic filariasis (LF) antigenemia. Annual mass drug administration (MDA) was conducted using single-dose albendazole plus diethylcarbamazine from 2000 to 2006. This study presents the results of a 2007 population-based PacELF C-survey in all ages and compares the adult filarial antigenemia results of this survey to those of a subsequent 2010 survey in adults with the aim of improving understanding of LF transmission after MDA.
  
  Results
  
  The 2007 C-survey used simple random sampling of households from a geolocated list. In 2007, the overall LF antigen prevalence by immunochromatographic card test (ICT) for all ages was 2.29% (95% CI 1.66–3.07). Microfilaremia prevalence was 0.27% (95% CI 0.09–0.62). Increasing age (OR 1.04 per year, 95% CI 1.02–1.05) was significantly associated with ICT positivity on multivariate analysis, while having ever taking MDA was protective (OR 0.39, 95% CI 0.16–0.96). The 2010 survey used a similar spatial sampling design.
  
  Conclusions
  
  After 7 years of MDA, with four rounds achieving effective coverage, a representative household survey in 2007 showed a decline in prevalence from 16.5 to 2.3% in all ages. However, lack of further decline in adult prevalence by 2010 and fluctuation at the village level showed that overall antigenemia prevalence at a broader scale may not provide an accurate reflection of ongoing transmission at the village level.
  
  
• Subjects:
  American Samoa Epidemiology Lymphatic Filariasis MDA PacELF Prevalence Research Wuchereria Bancrofti
• Source:
  Trop Med Health. 45.
• Pubmed ID:
  28794687
• Pubmed Central ID:
  PMC5543440
• Document Type:
  Journal Article
• Volume:
  45
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f3f7c26263d8621142ec63db739c4c2289c4f5593d8b9ff6ebc90473a21676ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/47495/cdc_47495_DS1.pdf
• File Type:
  [PDF - 838.46 KB ]