Details:

Alternative Title:
Cancer
Personal Author:
Giddings, Brenda M. ; Whitehead, Todd P. ; Metayer, Catherine ; Miller, Mark D.
Giddings, Brenda M. ; Whitehead, Todd P. ; Metayer, Catherine ; Miller, Mark D. Less -
Description:
Background

High rates of childhood leukemia incidence have been reported in Latin America and among Hispanic children in the United States. California’s large Hispanic population affords an important opportunity to perform a detailed analysis of the leukemia burden among Hispanic children.

Methods

Leukemias diagnosed among non-Hispanic white (NHW), Hispanic, African American (AA), and Asian/Pacific Islander (API) children, aged 0 to 19 years, between January 1, 1990 and December 31, 2012 were obtained from the California Cancer Registry (n=11,084). Age-adjusted incidence rates (AAIR), standardized rate ratios (SRR), and secular trends in incidence (annual percent change [APC]) were analyzed by subtype, race/ethnicity, sex, and age.

Results

Compared to NHWs, acute lymphoblastic leukemia (ALL) incidence was higher among Hispanics (SRR=1.32) and lower among AAs (SRR=0.55) and APIs (SRR=0.91). From 1990 to 2012, ALL incidence increased overall (APC=1.1%), among males (APC=1.0%), females (APC=1.3%), Hispanics (APC=1.1%), AAs (APC=1.9%), AA males (APC=2.8%), API males (APC=1.9%), and Hispanic females (APC=1.5%). ALL increased among Hispanic males aged 15 to 19 years (APC=2.5%) and Hispanic females aged 0 to 4 and 15 to 19 years (APC=2.2% and 1.9%, respectively). Acute myeloid leukemia (AML) incidence did not differ among racial/ethnic groups. From 1990 to 2012, overall AML incidence remained stable but increased among Hispanics (APC=1.2%), females (APC=1.0%), Hispanic females (APC=2.3%), and Hispanic females aged 15 to 19 years (APC=3.4%).

Conclusions

Notable differences in childhood leukemia incidence among four racial/ethnic groups in California were observed. Factors which may contribute to these differences include differential exposure to carcinogens and/or genetic susceptibility.


Subjects:
[+]
Adolescent Adult Child Child, Preschool Female Hispanic Or Latino Humans Incidence Male Precursor Cell Lymphoblastic Leukemia-Lymphoma Young Adult
Source:
Cancer. 122(18):2867-2875.
Pubmed ID:
27351365
Pubmed Central ID:
PMC5542672
Document Type:
Journal Article
Funding:
P01 ES018172/ES/NIEHS NIH HHS/United States ; P50 ES018172/ES/NIEHS NIH HHS/United States ; U61 TS000237/TS/ATSDR CDC HHS/United States
P01 ES018172/ES/NIEHS NIH HHS/United States ; P50 ES018172/ES/NIEHS NIH HHS/United States ; U61 TS000237/TS/ATSDR CDC HHS/United States Less -
Place as Subject:
California
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ff0d00837263fa3f28d1616656c2edc43824f2779c614109351d4dff2e643019
Download URL:
https://stacks.cdc.gov/view/cdc/47332/cdc_47332_DS1.pdf
File Type:

Supporting Files

• nihms872801.nxml

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