The role of symptomatic presentation in influenza A transmission risk

Wardell, Rebecca; Prem, Kiesha; Cowling, Benjamin J; Cook, Alex R

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The role of symptomatic presentation in influenza A transmission risk

Published Date:

Dec 05 2016

Source:

Epidemiol Infect. 145(4):723-727.

[PDF-385.65 KB]

Details:

Personal Authors:

Wardell, Rebecca ; Prem, Kiesha ; Cowling, Benjamin J ; Cook, Alex R ;

Keywords:

[+]

Pubmed ID:

27916020

Pubmed Central ID:

PMC5528871

Description:

Computer models can be useful in planning interventions against novel strains of influenza. However such models sometimes make unsubstantiated assumptions about the relative infectivity of asymptomatic and symptomatic cases, or conversely assume there is no impact at all. Using household-level data from known-index studies of virologically confirmed influenza A infection, the relationship between an individual's infectiousness and their symptoms was quantified using a discrete-generation transmission model and Bayesian Markov chain Monte Carlo methods. It was found that the presence of particular respiratory symptoms in an index case does not influence transmission probabilities, with the exception of child-to-child transmission where the donor has phlegm or a phlegmy cough.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U01 CI000439/CI/NCPDCID CDC HHS/United States
U54 GM088558/GM/NIGMS NIH HHS/United States

Supporting Files:

	NIHMS881044-supplement-Supporting_information.pdf	application/pdf
	nihms881044.nxml	text/xml
	nihms881044f1.gif	image/gif
	nihms881044f1.jpg	image/jpeg

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