Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls

Details

• Alternative Title:
  Epidemiology
• Personal Author:
  Deierlein, Andrea L. ; Wolff, Mary S. ; Pajak, Ashley ; Pinney, Susan M. ; Windham, Gayle C. ; Galvez, Maida P. ; Silva, Manori J. ; Calafat, Antonia M. ; Kushi, Lawrence H. ; Biro, Frank M. ; Teitelbaum, Susan L.
• Corporate Authors:
  Breast Cancer and Environment Research Program
• Description:
  Background
  
  Phthalates are environmental chemicals that may play a role in the development of obesity. Few studies have investigated longitudinal associations between postnatal phthalate exposures and subsequent anthropometric measurements in children.
  
  Methods
  
  We collected data as part of The Breast Cancer and Environment Research Program at three US sites. 1,239 girls, ages 6–8 years, were enrolled in 2004–2007. We categorized baseline phthalate exposures, assessed from creatinine-corrected urinary concentrations of low molecular weight phthalate metabolites as low, <78; medium, 78-<194; and high, ≥194 μg/g creatinine and of high molecular weight phthalates as low, <111; medium, 111–278; and high, ≥278 μg/g creatinine. Anthropometric measurements were collected through 2012 (n=1,017). Linear mixed effects regression estimated how baseline low and high molecular weight phthalate concentrations related to changes in girls’ body mass index (BMI), height, and waist circumference at ages 7 through 13 years.
  
  Results
  
  Low molecular weight phthalates were positively associated with gains in BMI and waist circumference. Predicted differences in BMI and waist circumference between girls with high versus low concentrations of low molecular weight phthalates increased from 0.56 (95% CI: −0.02, 1.1) to 1.2 (95%CI: 0.28, 2.1) kg/m2 and from 1.5 (95%CI: −0.38, 3.3) to 3.9 (95%CI: 1.3, 6.5) cm, respectively. High molecular weight phthalates were negatively associated with height but only among girls who were normal weight at baseline (BMI ≤85th percentile).
  
  Conclusion
  
  Phthalates, specifically low molecular weight phthalates, have small but detectable associations with girls’ anthropometric outcomes. Low molecular weight phthalates, showed stronger associations than other types of phthalates.
  
  
• Subjects:
  Adolescent Body Height Body Mass Index Body Weight Child Environmental Exposure Female Humans Linear Models Longitudinal Studies Obesity Phthalic Acids United States Waist Circumference

  More +
• Source:
  Epidemiology. 27(4):492-499
• Pubmed ID:
  27031039
• Pubmed Central ID:
  PMC5524128
• Document Type:
  Journal Article
• Funding:
  U01 ES012770/ES/NIEHS NIH HHSUnited States/ ; U01 ES012800/ES/NIEHS NIH HHSUnited States/ ; P01 ES009584/ES/NIEHS NIH HHSUnited States/ ; U01 ES012771/ES/NIEHS NIH HHSUnited States/ ; P30 ES006096/ES/NIEHS NIH HHSUnited States/ ; P30 ES023515/ES/NIEHS NIH HHSUnited States/ ; T32 HD049311/HD/NICHD NIH HHSUnited States/ ; U01 ES012801/ES/NIEHS NIH HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/ ; U01 ES019453/ES/NIEHS NIH HHSUnited States/ ; U01 ES019457/ES/NIEHS NIH HHSUnited States/ ; U01 ES019454/ES/NIEHS NIH HHSUnited States/ ; UL1 RR029887/RR/NCRR NIH HHSUnited States/ ; U01 ES019435/ES/NIEHS NIH HHSUnited States/ ; R00 ES023474/ES/NIEHS NIH HHSUnited States/
• Volume:
  27
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:19727e8dd12ae7cacbe7e7a87c9bc6b22a6de4b68d676f3764a599d97f66f742
• Download URL:
  https://stacks.cdc.gov/view/cdc/46889/cdc_46889_DS1.pdf
• File Type:
  [PDF - 410.43 KB ]