Details:

Alternative Title:
Epidemiology
Personal Author:
Deierlein, Andrea L. ; Wolff, Mary S. ; Pajak, Ashley ; Pinney, Susan M. ; Windham, Gayle C. ; ... More +
Deierlein, Andrea L. ; Wolff, Mary S. ; Pajak, Ashley ; Pinney, Susan M. ; Windham, Gayle C. ; Galvez, Maida P. ; Silva, Manori J. ; Calafat, Antonia M. ; Kushi, Lawrence H. ; Biro, Frank M. ; Teitelbaum, Susan L. Less -
Corporate Authors:
Breast Cancer and Environment Research Program
Description:
Background

Phthalates are environmental chemicals that may play a role in the development of obesity. Few studies have investigated longitudinal associations between postnatal phthalate exposures and subsequent anthropometric measurements in children.

Methods

We collected data as part of The Breast Cancer and Environment Research Program at three US sites. 1,239 girls, ages 6–8 years, were enrolled in 2004–2007. We categorized baseline phthalate exposures, assessed from creatinine-corrected urinary concentrations of low molecular weight phthalate metabolites as low, <78; medium, 78-<194; and high, ≥194 μg/g creatinine and of high molecular weight phthalates as low, <111; medium, 111–278; and high, ≥278 μg/g creatinine. Anthropometric measurements were collected through 2012 (n=1,017). Linear mixed effects regression estimated how baseline low and high molecular weight phthalate concentrations related to changes in girls’ body mass index (BMI), height, and waist circumference at ages 7 through 13 years.

Results

Low molecular weight phthalates were positively associated with gains in BMI and waist circumference. Predicted differences in BMI and waist circumference between girls with high versus low concentrations of low molecular weight phthalates increased from 0.56 (95% CI: −0.02, 1.1) to 1.2 (95%CI: 0.28, 2.1) kg/m2 and from 1.5 (95%CI: −0.38, 3.3) to 3.9 (95%CI: 1.3, 6.5) cm, respectively. High molecular weight phthalates were negatively associated with height but only among girls who were normal weight at baseline (BMI ≤85th percentile).

Conclusion

Phthalates, specifically low molecular weight phthalates, have small but detectable associations with girls’ anthropometric outcomes. Low molecular weight phthalates, showed stronger associations than other types of phthalates.


Subjects:
[+]
Adolescent Body Height Body Mass Index Body Weight Child Environmental Exposure Female Humans Linear Models Longitudinal Studies Obesity Phthalic Acids Waist Circumference
Source:
Epidemiology. 27(4):492-499.
Pubmed ID:
27031039
Pubmed Central ID:
PMC5524128
Document Type:
Journal Article
Funding:
U01 ES012770/ES/NIEHS NIH HHS/United States ; U01 ES012800/ES/NIEHS NIH HHS/United States ; P01 ES009584/ES/NIEHS NIH HHS/United States ; U01 ES012771/ES/NIEHS NIH HHS/United States ; P30 ES006096/ES/NIEHS NIH HHS/United States ; ... More +
U01 ES012770/ES/NIEHS NIH HHS/United States ; U01 ES012800/ES/NIEHS NIH HHS/United States ; P01 ES009584/ES/NIEHS NIH HHS/United States ; U01 ES012771/ES/NIEHS NIH HHS/United States ; P30 ES006096/ES/NIEHS NIH HHS/United States ; P30 ES023515/ES/NIEHS NIH HHS/United States ; T32 HD049311/HD/NICHD NIH HHS/United States ; U01 ES012801/ES/NIEHS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; U01 ES019453/ES/NIEHS NIH HHS/United States ; U01 ES019457/ES/NIEHS NIH HHS/United States ; U01 ES019454/ES/NIEHS NIH HHS/United States ; UL1 RR029887/RR/NCRR NIH HHS/United States ; U01 ES019435/ES/NIEHS NIH HHS/United States ; R00 ES023474/ES/NIEHS NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:19727e8dd12ae7cacbe7e7a87c9bc6b22a6de4b68d676f3764a599d97f66f742
Download URL:
https://stacks.cdc.gov/view/cdc/46889/cdc_46889_DS1.pdf
File Type:

Supporting Files

• 	NIHMS866942-supplement-Supplemental_Digital_Content.pdf	pdf
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