Mortality Among Workers Exposed to Toluene Diisocyanate in the US Polyurethane Foam Industry: Update and Exposure-Response Analyses

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Pinkerton, Lynne E. ; Yiin, James H. ; Daniels, Robert D. ; Fent, Kenneth W.
• Description:
  Background
  
  Mortality among 4,545 toluene diisocyante (TDI)-exposed workers was updated through 2011. The primary outcome of interest was lung cancer.
  
  Methods
  
  Life table analyses, including internal analyses by exposure duration and cumulative TDI exposure, were conducted.
  
  Results
  
  Compared with the US population, all cause and all cancer mortality was increased. Lung cancer mortality was increased but was not associated with exposure duration or cumulative TDI exposure. In post hoc analyses, lung cancer mortality was associated with employment duration in finishing jobs, but not in finishing jobs involving cutting polyurethane foam.
  
  Conclusions
  
  Dermal exposure, in contrast to inhalational exposure, to TDI is expected to be greater in finishing jobs and may play a role in the observed increase in lung cancer mortality. Limitations include the lack of smoking data, uncertainty in the exposure estimates, and exposure estimates that reflected inhalational exposure only.
  
  
• Subjects:
  Adult Aged Chemical Industry Female Follow-Up Studies Humans Life Tables Lung Neoplasms Male Middle Aged Occupational Exposure Polyurethanes Time Factors Toluene 2,4-Diisocyanate

  More +
• Source:
  Am J Ind Med. 59(8):630-643.
• Pubmed ID:
  27346061
• Pubmed Central ID:
  PMC5511732
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  59
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5c21e419629c4b6b32937e2246473a26adc6ae33bdc0ef55f3cc5e866b3dfbdf
• Download URL:
  https://stacks.cdc.gov/view/cdc/46818/cdc_46818_DS1.pdf
• File Type:
  [PDF - 416.89 KB ]