Details:

Alternative Title:
Obstet Gynecol
Personal Author:
Parra-Saavedra, Miguel ; Reefhuis, Jennita ; Piraquive, Juan Pablo ; Gilboa, Suzanne M. ; Badell, Martina L. ; ... More +
Parra-Saavedra, Miguel ; Reefhuis, Jennita ; Piraquive, Juan Pablo ; Gilboa, Suzanne M. ; Badell, Martina L. ; Moore, Cynthia A. ; Mercado, Marcela ; Valencia, Diana ; Jamieson, Denise J. ; Beltran, Mauricio ; Sanz-Cortes, Magda ; Rivera-Casas, Ana Maria ; Yepez, Mayel ; Parra, Guido ; Martinez, Martha Ospina ; Honein, Margaret A. Less -
Description:
Objective

To evaluate fetal ultrasound and magnetic resonance imaging findings among a series of pregnant women with confirmed Zika virus infection to evaluate the signs of congenital Zika syndrome with respect to timing of infection.

Methods

Retrospective case series of pregnant women referred to two perinatal clinics in Barranquilla and Ibagué, Colombia with findings consistent with congenital Zika syndrome and Zika virus infection confirmed in maternal, fetal, or infant samples. Serial ultrasound measurements, fetal magnetic resonance imaging results, laboratory results, and perinatal outcomes were evaluated.

Results

We describe 17 cases of confirmed prenatal maternal Zika virus infection with adverse fetal outcomes. Among the 14 symptomatic women, the median gestational age for maternal Zika virus symptoms was 10 weeks (range 7–14). The median time between Zika virus symptom onset and microcephaly (head circumference less than 3 standard deviations below the mean) was 18 weeks (range 15–24). The earliest fetal head circumference measurement consistent with microcephaly diagnosis was at 24 weeks of gestation. The earliest sign of congenital Zika syndrome was talipes equinovarus, which in two patients was noted first at 19 weeks. Common findings on fetal magnetic resonance imaging were microcephaly, ventriculomegaly, polymicrogyria, and calcifications.

Conclusion

Our analysis suggests a period of at least 15 weeks between maternal Zika virus infection in pregnancy and development of microcephaly, and highlights the importance of serial and detailed neuroimaging.


Subject:
[+]
Adolescent
Adult
Article
Congenital Abnormalities
Female
Humans
Male
Microcephaly
Neuroimaging
Pregnancy
Pregnancy Complications, Infectious
Retrospective Studies
Ultrasonography, Prenatal
Young Adult
Zika Virus
Zika Virus Infection

Source:
Obstet Gynecol. 130(1):207-212.
Pubmed ID:
28594771
Pubmed Central ID:
PMC5511628
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Colombia
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:58f7c26ade9ad71dfaa76d4368ea7287b420d26d8e84de7525f48c369dbacecb
File Type:

Supporting Files

• 	NIHMS874438-supplement-Supplemental_Digital_Content.pdf	pdf
  	nihms874438.nxml	xml
  	nihms874438f1.gif	gif
  	nihms874438f1.jpg	jpeg

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