Details:

Alternative Title:
Transpl Infect Dis
Personal Author:
Brondfield, MN ; Reid, MR ; Rutishauser, RL ; Cope, JR ; Tang, J ; ... More +
Brondfield, MN ; Reid, MR ; Rutishauser, RL ; Cope, JR ; Tang, J ; Ritter, JM ; Matanock, A ; Ali, I ; Doernberg, SB ; Hilts-Horeczko, A ; DeMarco, T ; Klein, L ; Babik, JM Less -
Description:
Disseminated acanthamoebiasis is a rare, often fatal, infection most commonly affecting immunocompromised patients. We report a case involving sinuses, skin, and bone in a 60-year-old woman 5 months after heart transplantation. She improved with a combination of flucytosine, fluconazole, miltefosine, and decreased immunosuppression. To our knowledge, this is the first case of successfully treated disseminated acanthamoebiasis in a heart transplant recipient and only the second successful use of miltefosine for this infection among solid organ transplant recipients. Acanthamoeba infection should be considered in transplant recipients with evidence of skin, central nervous system, and sinus infections that are unresponsive to antibiotics. Miltefosine may represent an effective component of a multidrug therapeutic regimen for the treatment of this amoebic infection.
Subject:
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Acanthamoeba Amebiasis Amebicides Amphotericin B Anti-Bacterial Agents Antilymphocyte Serum Article Biopsy Cardiomyopathies Drugs, Investigational Endoscopy Female Fluconazole Flucytosine Heart Transplantation Humans Immunocompromised Host Immunosuppressive Agents Magnetic Resonance Imaging Metacarpal Bones Metronidazole Middle Aged Phosphorylcholine Polymerase Chain Reaction Radiography Sinusitis Skin
Source:
Transpl Infect Dis. 19(2).
Pubmed ID:
28067969
Pubmed Central ID:
PMC5510642
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7fdb0ba693ae023d3b435092410167d2c5d03e16f92fc26cec61e7bbbdec0c73
Download URL:
https://stacks.cdc.gov/view/cdc/46716/cdc_46716_DS1.pdf
File Type:

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