Details:

Alternative Title:
Early Hum Dev
Personal Author:
Jeddy, Zuha; Hartman, Terryl J.; Taylor, Ethel V.; Poteete, Cayla; Kordas, Katarzyna;
Jeddy, Zuha; Hartman, Terryl J.; Taylor, Ethel V.; Poteete, Cayla; Kordas, Katarzyna; Less -
Description:
Perfluoroalkyl substances (PFAS), found in many household products and classed as endocrine disrupting chemicals, can be transferred through the placenta and are associated with multiple developmental deficits in offspring. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the association between intrauterine exposure to PFAS and early communication development in 432 mother-daughter dyads at 15 and 38months of age. Concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) were measured in maternal serum collected during pregnancy. Early communication development was measured with the ALSPAC-adapted MacArthur Communicative Development Inventories for Infants and Toddlers. The infant questionnaire measured verbal comprehension, vocabulary comprehension and production, nonverbal communication, and social development. The toddler questionnaire measured language, intelligibility, and communicative sub-scores. Multivariable linear regression was used to examine associations between each PFAS exposure and each communication sub-scale score. The association between maternal PFAS concentrations and early communication development at 15 and 38months of age varied by maternal age at delivery. In daughters of younger mothers (<25years of age), every 1ng/mL of PFOS was associated with a 3.82 point (95% confidence interval (CI): -6.18, -1.47) lower vocabulary score at 15months and a 0.80 point (95% CI: -1.74, 0.14) lower language score at 38months. Prenatal exposure to select PFAS was positively and negatively associated with communication development among girls, with inconsistent pattern of association across all measured PFAS and endpoints.
Subject:
[+]
ALSPAC
Article
Child
Communication Skills
Girls
Language
PFAS

Source:
Early Hum Dev. 109:15-20.;
Pubmed ID:
28411449
Pubmed Central ID:
PMC5507173
Document Type:
Journal Article;
Funding:
Wellcome Trust/United Kingdom; CC999999/Intramural CDC HHS/United States; MC_PC_15018/Medical Research Council/United Kingdom; Medical Research Council/United Kingdom;
Wellcome Trust/United Kingdom; CC999999/Intramural CDC HHS/United States; MC_PC_15018/Medical Research Council/United Kingdom; Medical Research Council/United Kingdom; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b8f67a15ec19078fce92abbd477614faba590c6664af1475ed8ac6dd8931c0c1
File Type:

Supporting Files

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