Details:

Alternative Title:
BJOG
Personal Author:
Dunietz, Galit Levi; Strutz, Kelly L.; Holzman, Claudia; Tian, Yan; Todem, David; ... More +
Dunietz, Galit Levi; Strutz, Kelly L.; Holzman, Claudia; Tian, Yan; Todem, David; Bullen, Bertha L.; Catov, Janet M.; Less -
Description:
Objective Hypertensive disorders in pregnancy signal an increased risk of cardiovascular disease for women. However, future hypertension risk among pregnant women with moderately elevated blood pressure (BP) is unknown. We examined associations among moderately elevated BP or hypertensive disorders during pregnancy and later prehypertension or hypertension. Design Longitudinal cohort study. Setting Five communities in Michigan, USA. Sample Data are from pregnant women enrolled in the Pregnancy Outcomes and Community Health Study. We included 667 women with gestational BP measurements who participated in the POUCHmoms Study follow-up 7-15 years later. Methods Moderately elevated BP was defined as two measures of systolic BP ≥120 mmHg or diastolic BP ≥80 mmHg among women without a hypertensive disorder. Weighted multinomial logistic regression models estimated odds of prehypertension or hypertension at follow-up, adjusted for maternal confounders and time to follow-up. Main Outcome Measures Prehypertension or hypertension. Results Women meeting the moderately elevated BP criteria (64%) had significantly higher odds of hypertension at follow-up (adjusted odds ratio =2.6; 95% confidence interval: 1.2-5.5). These increased odds were observed for moderately elevated BP first identified before or after 20 weeks, and for elevated systolic BP alone or combined with elevated diastolic BP. Conclusions Moderately elevated BP in pregnancy may be a risk factor for future hypertension. Pregnancy offers an opportunity to identify women at risk for hypertension who may not have been identified otherwise.
Subject:
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Adult
Blood Pressure
Female
Follow-Up Studies
Humans
Hypertension
Logistic Models
Longitudinal Studies
Odds Ratio
Pregnancy
Pregnancy Complications, Cardiovascular
Prehypertension
Risk Factors
Young Adult

Source:
BJOG. 124(10):1606-1613;
Pubmed ID:
28074637
Pubmed Central ID:
PMC5505807
Document Type:
Journal Article;
Funding:
T32 HD046377/HD/NICHD NIH HHS/United States; R01 HL103825/HL/NHLBI NIH HHS/United States; R01 HD034543/HD/NICHD NIH HHS/United States; T32 NS007222/NS/NINDS NIH HHS/United States; U01 DP000143/DP/NCCDPHP CDC HHS/United States;
T32 HD046377/HD/NICHD NIH HHS/United States; R01 HL103825/HL/NHLBI NIH HHS/United States; R01 HD034543/HD/NICHD NIH HHS/United States; T32 NS007222/NS/NINDS NIH HHS/United States; U01 DP000143/DP/NCCDPHP CDC HHS/United States; Less -
Place as Subject:
Michigan;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:54b764b119e736b87f15677b7d8c33a68e90da05197bf8ad2fc396e07715ee98
File Type:

Supporting Files

• 	NIHMS842693-supplement-Supp_TableS1.pdf	pdf
  	NIHMS842693-supplement-Supp_TableS2.pdf	pdf
  	NIHMS842693-supplement-Supp_TableS3.pdf	pdf
  	nihms842693.nxml	xml
  	nihms842693f1.gif	gif
  	nihms842693f1.jpg	jpeg

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