Details:

Alternative Title:
BJOG
Personal Author:
Dunietz, Galit Levi ; Strutz, Kelly L. ; Holzman, Claudia ; Tian, Yan ; Todem, David ; ... More +
Dunietz, Galit Levi ; Strutz, Kelly L. ; Holzman, Claudia ; Tian, Yan ; Todem, David ; Bullen, Bertha L. ; Catov, Janet M. Less -
Description:
Objective

Hypertensive disorders in pregnancy signal an increased risk of cardiovascular disease for women. However, future hypertension risk among pregnant women with moderately elevated blood pressure (BP) is unknown. We examined associations among moderately elevated BP or hypertensive disorders during pregnancy and later prehypertension or hypertension.

Design

Longitudinal cohort study.

Setting

Five communities in Michigan, USA.

Sample

Data are from pregnant women enrolled in the Pregnancy Outcomes and Community Health Study. We included 667 women with gestational BP measurements who participated in the POUCHmoms Study follow-up 7-15 years later.

Methods

Moderately elevated BP was defined as two measures of systolic BP ≥120 mmHg or diastolic BP ≥80 mmHg among women without a hypertensive disorder. Weighted multinomial logistic regression models estimated odds of prehypertension or hypertension at follow-up, adjusted for maternal confounders and time to follow-up.

Main Outcome Measures

Prehypertension or hypertension.

Results

Women meeting the moderately elevated BP criteria (64%) had significantly higher odds of hypertension at follow-up (adjusted odds ratio =2.6; 95% confidence interval: 1.2-5.5). These increased odds were observed for moderately elevated BP first identified before or after 20 weeks, and for elevated systolic BP alone or combined with elevated diastolic BP.

Conclusions

Moderately elevated BP in pregnancy may be a risk factor for future hypertension. Pregnancy offers an opportunity to identify women at risk for hypertension who may not have been identified otherwise.


Keywords:
[+]
Adult Blood Pressure Diastolic Pressure Female Follow-Up Studies Humans Hypertension Logistic Models Longitudinal Studies Michigan Odds Ratio Pregnancy Pregnancy Complications, Cardiovascular Prehypertension Risk Factors Systolic Pressure Young Adult
Source:
BJOG. 124(10):1606-1613
Pubmed ID:
28074637
Pubmed Central ID:
PMC5505807
Document Type:
Journal Article
Funding:
T32 HD046377/HD/NICHD NIH HHSUnited States/ ; R01 HL103825/HL/NHLBI NIH HHSUnited States/ ; R01 HD034543/HD/NICHD NIH HHSUnited States/ ; T32 NS007222/NS/NINDS NIH HHSUnited States/ ; U01 DP000143/DP/NCCDPHP CDC HHSUnited States/
T32 HD046377/HD/NICHD NIH HHSUnited States/ ; R01 HL103825/HL/NHLBI NIH HHSUnited States/ ; R01 HD034543/HD/NICHD NIH HHSUnited States/ ; T32 NS007222/NS/NINDS NIH HHSUnited States/ ; U01 DP000143/DP/NCCDPHP CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:54b764b119e736b87f15677b7d8c33a68e90da05197bf8ad2fc396e07715ee98
Download URL:
https://stacks.cdc.gov/view/cdc/46700/cdc_46700_DS1.pdf
File Type:

Supporting Files

• 	NIHMS842693-supplement-Supp_TableS1.pdf	pdf
  	NIHMS842693-supplement-Supp_TableS2.pdf	pdf
  	NIHMS842693-supplement-Supp_TableS3.pdf	pdf
  	nihms842693.nxml	xml
  	nihms842693f1.gif	gif
  	nihms842693f1.jpg	jpeg

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