Secondary conditions among males with Duchenne or Becker muscular dystrophy

Details

• Alternative Title:
  J Child Neurol
• Personal Author:
  Latimer, Rebecca ; Street, Natalie ; Conway, Kristin Caspers ; James, Kathy ; Cunniff, Christopher ; Oleszek, Joyce ; Fox, Deborah ; Ciafaloni, Emma ; Westfield, Christina ; Paramsothy, Pangaja
• Corporate Authors:
  Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STAR
• Description:
  Duchenne and Becker muscular dystrophy are X-linked neuromuscular disorders characterized by progressive muscle degeneration. Despite the involvement of multiple systems, secondary conditions among affected males have not been comprehensively described. Two hundred nine caregivers of affected males (aged 3-31 years) identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network completed a mailed survey that included questions about secondary conditions impacting multiple body functions. The 5 most commonly reported conditions in males with Duchenne were cognitive deficits (38.4%), constipation (31.7%), anxiety (29.3%), depression (27.4%), and obesity (19.5%). Higher frequencies of anxiety, depression, and kidney stones were found among nonambulatory males compared to ambulatory males. Attention-deficit hyperactivity disorder (ADHD) was more common in ambulatory than nonambulatory males. These data support clinical care recommendations for monitoring of patients with Duchenne or Becker muscular dystrophy by a multidisciplinary team to prevent and treat conditions that may be secondary to the diagnosis.
• Subjects:
  Adolescent Adult Anxiety Child Child, Preschool Cognition Disorders Comorbidity Constipation Depression Health Surveys Humans Male Muscular Dystrophy, Duchenne Obesity Population Surveillance Prevalence Young Adult

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• Source:
  J Child Neurol. 32(7):663-670.
• Pubmed ID:
  28393671
• Pubmed Central ID:
  PMC5502756
• Document Type:
  Journal Article
• Funding:
  U01 DD001126/DD/NCBDD CDC HHS/United States ; U01 DD000187/DD/NCBDD CDC HHS/United States ; U01 DD001123/DD/NCBDD CDC HHS/United States ; U01DD001123/ACL HHS/United States ; U01 DD000189/DD/NCBDD CDC HHS/United States ; U01DD001119/ACL HHS/United States ; CC999999/Intramural CDC HHS/United States ; U01 DD000191/DD/NCBDD CDC HHS/United States ; U01 DD001119/DD/NCBDD CDC HHS/United States ; U01 DD000190/DD/NCBDD CDC HHS/United States
• Volume:
  32
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7bce9f4eaf9417691b02073d401400f5f28165bc7a7c7d41e914bbbb071b0d98
• Download URL:
  https://stacks.cdc.gov/view/cdc/46680/cdc_46680_DS1.pdf
• File Type:
  [PDF - 632.91 KB ]