Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Cragan, Janet D. ; Isenburg, Jennifer L. ; Parker, Samantha E. ; Alverson, C.J. ; Meyer, Robert E. ; ... More +
Cragan, Janet D. ; Isenburg, Jennifer L. ; Parker, Samantha E. ; Alverson, C.J. ; Meyer, Robert E. ; Stallings, Erin B. ; Kirby, Russell S. ; Lupo, Philip J. ; Liu, Jennifer S. ; Seagroves, Amanda ; Ethen, Mary K. ; Cho, Sook Ja ; Evans, MaryAnn ; Liberman, Rebecca F. ; Fornoff, Jane ; Browne, Marilyn L. ; Rutkowski, Rachel E. ; Nance, Amy E. ; Anderka, Marlene ; Fox, Deborah J. ; Steele, Amy ; Copeland, Glenn ; Romitti, Paul A. ; Mai, Cara T. Less -
Description:
Background

Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging.

Methods

Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,000 live births was estimated overall and by maternal/infant characteristics. Variation in prevalence was examined across case finding methods. Nine programs provided data on head circumference and conditions potentially contributing to microcephaly.

Results

The pooled prevalence of microcephaly was 8.7 per 10,000 live births. Median prevalence (per 10,000 live births) was similar among programs using active (6.7) and passive (6.6) methods; the interdecile range of prevalence estimates was wider among programs using passive methods for all race/ethnicity categories except Hispanic. Prevalence (per 10,000 live births) was lowest among non-Hispanic Whites (6.5) and highest among non-Hispanic Blacks and Hispanics (11.2 and 11.9, respectively); estimates followed a U-shaped distribution by maternal age with the highest prevalence among mothers <20 years (11.5) and ≥40 years (13.2). For gestational age and birth weight, the highest prevalence was among infants <32 weeks gestation and infants <1500 gm. Case definitions varied; 41.8% of cases had an HC ≥ the 10th percentile for sex and gestational age.

Conclusion

Differences in methods, population distribution of maternal/infant characteristics, and case definitions for microcephaly can contribute to the wide range of observed prevalence estimates across individual birth defects surveillance programs. Addressing these factors in the setting of Zika virus infection can improve the quality of prevalence estimates.


Subjects:
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Article Epidemiological Monitoring Female Humans Infant, Newborn Male Microcephaly Prevalence Retrospective Studies Zika Virus Zika Virus Infection
Source:
Birth Defects Res A Clin Mol Teratol. 106(11):972-982.
Pubmed ID:
27891783
Pubmed Central ID:
PMC5485911
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b37c54b7468398f1e2bdbb2fbf57be306710e451e784f9e2be96f8843b53f99a
Download URL:
https://stacks.cdc.gov/view/cdc/46444/cdc_46444_DS1.pdf
File Type:

Supporting Files

• 	NIHMS860543-supplement-Supplemental.pdf	pdf
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