Details:

Alternative Title:
Pharm Technol Hosp Pharm
Personal Author:
Connor, Thomas H. ; Smith, Jerome P.
Connor, Thomas H. ; Smith, Jerome P. Less -
Description:
Purpose

At the present time, the method of choice to determine surface contamination of the workplace with antineoplastic and other hazardous drugs is surface wipe sampling and subsequent sample analysis with a variety of analytical techniques. The purpose of this article is to review current methodology for determining the level of surface contamination with hazardous drugs in healthcare settings and to discuss recent advances in this area. In addition it will provide some guidance for conducting surface wipe sampling and sample analysis for these drugs in healthcare settings.

Methods

Published studies on the use of wipe sampling to measure hazardous drugs on surfaces in healthcare settings drugs were reviewed. These studies include the use of well-documented chromatographic techniques for sample analysis in addition to newly evolving technology that provides rapid analysis of specific antineoplastic

Results

Methodology for the analysis of surface wipe samples for hazardous drugs are reviewed, including the purposes, technical factors, sampling strategy, materials required, and limitations. The use of lateral flow immunoassay (LFIA) and fluorescence covalent microbead immunosorbent assay (FCMIA) for surface wipe sample evaluation is also discussed.

Conclusions

Current recommendations are that all healthcare settings where antineoplastic and other hazardous drugs are handled include surface wipe sampling as part of a comprehensive hazardous drug-safe handling program. Surface wipe sampling may be used as a method to characterize potential occupational dermal exposure risk and to evaluate the effectiveness of implemented controls and the overall safety program. New technology, although currently limited in scope, may make wipe sampling for hazardous drugs more routine, less costly, and provide a shorter response time than classical analytical techniques now in use.


Subjects:
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Article
Source:
Pharm Technol Hosp Pharm. 1(3):107-114
Pubmed ID:
28459100
Pubmed Central ID:
PMC5406133
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:17053b4cdd4ab2c749819ff2cce36d289888e0ecc9bc5659bdc1ac50649ffb80
Download URL:
https://stacks.cdc.gov/view/cdc/46312/cdc_46312_DS1.pdf
File Type:

Supporting Files

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