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Risk factors for transmission of tuberculosis among United States-born African Americans and Whites
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12 2015
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Source: Int J Tuberc Lung Dis. 19(12):1485-1492
[PDF-650.88 KB]
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Alternative Title:Int J Tuberc Lung Dis
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Description:SETTING
Tuberculosis (TB) patients and their contacts enrolled in nine states and the District of Columbia from 16 December 2009 to 31 March 2011.
OBJECTIVE
To evaluate characteristics of TB patients that are predictive of tuberculous infection in their close contacts.
DESIGN
The study population was enrolled from a list of eligible African-American and White TB patients from the TB registry at each site. Information about close contacts was abstracted from the standard reports of each site.
RESULTS
Close contacts of African-American TB patients had twice the risk of infection of contacts of White patients (adjusted risk ratio [aRR] 2.1, 95%CI 1.3–3.4). Close contacts of patients whose sputum was positive for acid-fast bacilli on sputum smear microscopy had 1.6 times the risk of tuberculous infection compared to contacts of smear-negative patients (95%CI 1.1–2.3). TB patients with longer (>3 months) estimated times to diagnosis did not have higher proportions of infected contacts (aRR 1.2, 95%CI 0.9–1.6).
CONCLUSION
African-American race and sputum smear positivity were predictive of tuberculous infection in close contacts. This study did not support previous findings that longer estimated time to diagnosis predicted tuberculous infection in contacts.
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Pubmed ID:26614190
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Pubmed Central ID:PMC5451108
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