IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE

Details

• Alternative Title:
  J Exp Med
• Personal Author:
  Hirsch, Martin S. ; Murphy, Frederick A. ; Hicklin, Martin D.
• Description:
  Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.
• Subjects:
  Animals Animals, Newborn Brain Complement Fixation Tests Female Fluorescent Antibody Technique Glomerulonephritis Graft Vs Host Disease Immune Sera Kidney Liver Lung Lymphocytic Choriomeningitis Male Musculoskeletal System Pancreas Rabbits Rats Thymus Gland

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• Source:
  J Exp Med. 127(4):757-766.
• Pubmed ID:
  4868581
• Pubmed Central ID:
  PMC2138472
• Document Type:
  Journal Article
• Volume:
  127
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0f98944648af001808ab826a9da82075f8bf5afec26e2702eb81ba4ac9df5071
• Download URL:
  https://stacks.cdc.gov/view/cdc/45147/cdc_45147_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]