IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE

Hirsch, Martin S.; Murphy, Frederick A.; Hicklin, Martin D.

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IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE

Published Date:

Apr 01 1968

Source:

J Exp Med. 127(4):757-766.

[PDF-1.01 MB]

Details:

Alternative Title:

J Exp Med

Personal Author:

Hirsch, Martin S. ; Murphy, Frederick A. ; Hicklin, Martin D. ;

Description:

Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.

Subject:

[+]

Pubmed ID:

4868581

Pubmed Central ID:

PMC2138472

Document Type:

Journal Article

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

757.nxml

application/octet-stream

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IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE

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