Details:

Alternative Title:
J Exp Med
Personal Author:
Hirsch, Martin S.; Murphy, Frederick A.; Hicklin, Martin D.;
Hirsch, Martin S.; Murphy, Frederick A.; Hicklin, Martin D.; Less -
Description:
Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.
Subject:
[+]
Animals
Animals, Newborn
Brain
Complement Fixation Tests
Female
Fluorescent Antibody Technique
Glomerulonephritis
Graft Vs Host Disease
Immune Sera
Kidney
Liver
Lung
Lymphocytic Choriomeningitis
Male
Musculoskeletal System
Pancreas
Rabbits
Rats
Thymus Gland

Source:
J Exp Med. 127(4):757-766.;
Pubmed ID:
4868581
Pubmed Central ID:
PMC2138472
Document Type:
Journal Article;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0f98944648af001808ab826a9da82075f8bf5afec26e2702eb81ba4ac9df5071
File Type:

Supporting Files

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