NIOSH Skin Notation (SK) Profile: Acrylic Acid [CAS No. 79-10-7]

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  Although no studies were identified that fully evaluated potential systemic effects following repeated or prolonged dermal exposure, sufficient data were identified from dermal absorption and penetration studies in animals [Basic Acrylic Monomer Manufacturers 1993; Winter and Sipes 1993; Black et al. 1995] and acute dermal toxicity studies in rabbits [Smyth et al. 1962; Carpenter et al. 1974] to show that acrylic acid has the potential to be absorbed through the skin and is acutely toxic following dermal exposure. Undiluted acrylic acid [Smyth et al. 1962; Carpenter et al. 1974;] and possibly concentrations greater that 5% are corrosive to rabbit or rat skin, whereas concentrations up to 5% may be irritating to the skin [DePass et al. 1984]. Results from skin sensitization studies suggest that distilled acrylic acid is not likely to be a skin sensitizer, whereas commercial preparations using methods that do not include distillation are likely to contain impurities or polymerization inhibitors that are potential skin sensitizers [Waegemaekers and van der Walle 1984; IPCS 1997]. Therefore, on the basis of these assessments, acrylic acid is assigned a composite skin notation of SK: SYS-DIR (COR). Table 3 summarizes the skin hazard designations for acrylic acid previously issued by NIOSH and other organizations. The equivalent dermal designations for acrylic acid, according to the Globally Harmonized System (GHS) for Classification and Labelling of Chemicals, are Acute Toxicity Category 4 (Hazard statement: Harmful in contact with the skin) and Skin Corrosion Category 1A (Hazard statement: Causes severe skin burns and eye damage) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Acrylates Acrylic Resins Animals Corrosion Dermatitis, Occupational Environmental Exposure Epidemiology Hazardous Substances Laboratories Occupational Exposure Occupational Health Polymers Risk Assessment Risk Factors Safety Skin Skin Absorption Skin Diseases Toxicology

  More +
• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute-toxicity; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Lethal-dose; Dermal-exposure; Acrylic acid; Dermal absorption; Corrosives; Skin irritants; Polymerization; Sensitizers; Exposure assessment
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-133, 2017 Apr; :1-9
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20049603
• NTIS Accession Number:
  PB2017-102214
• CAS Registry Number:
  Acrylic acid (CAS RN 79-10-7)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dea1e275158873aebd5311a8b62740c9ec60f8634e2a92356f502babb324df9782bdd3a533887b72a59eb3c4bc5c460a2cc466e26d7188f1e6f906c8389e1a2a
• Download URL:
  https://stacks.cdc.gov/view/cdc/45058/cdc_45058_DS1.pdf
• File Type:
  [PDF - 232.62 KB ]