NIOSH Skin Notation (SK) Profile: Dioxathion [CAS No. 78-34-2]

Details

• Journal Article:
  National Institute for Occupational Safety and Healtho
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  No toxicokinetic data on humans or animals and no case reports, epidemiological studies, or repeated-dose, subchronic, or chronic toxicity studies in animals were identified that evaluated the potential of dioxathion to be absorbed through the skin or to cause systemic effects following dermal exposure. Although a predictive model indicates that dioxathion has low potential to be absorbed through the skin and be systemically available, acute dermal toxicity studies in rats and rabbits [Frawley et al. 1963; Gaines 1969] indicate that dioxathion is absorbed through the skin, is systemically available, and can be fatal at low doses following dermal exposure. No in vitro tests, case reports, or standard skin irritation tests were identified that evaluated the potential of dioxathion to produce direct effects on the skin. No diagnostic tests in humans or predictive tests in animals were identified to adequately evaluate the potential of dioxathion to cause skin sensitization. Therefore, on the basis of these assessments, dioxathion is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for dioxathion previously issued by NIOSH and other organizations. The equivalent dermal designations for dioxathion, according to the Globally Harmonized System (GHS) for Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Animals Dermatitis, Occupational Environmental Exposure Epidemiology Hazardous Substances Laboratories Mortality Occupational Exposure Occupational Health Organothiophosphorus Compounds Risk Assessment Risk Factors Safety Skin Skin Absorption Skin Diseases Toxicology

  More +
• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute-toxicity; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Lethal-dose; Dermal-exposure; Dioxathion; Skin absorption; Mortality data; Exposure assessment
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-135, 2017 Apr; :1-7
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  20 pdf apges
• NIOSHTIC Number:
  nn:20049605
• NTIS Accession Number:
  PB2017-102216
• CAS Registry Number:
  Dioxathion (CAS RN 78-34-2)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2ff5b9fb6ad8c88b25eaa0007db186b71c62486d028539866b209cd0e1283c4f7fb0a20fd657df05f98ef82b93690cd6e47f16e4942caf295b164d94f013f7d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/45056/cdc_45056_DS1.pdf
• File Type:
  [PDF - 223.12 KB ]