NIOSH Skin Notation (SK) Profile: Ethyl P-Nitrophenyl Phenylphosphorothioate (EPN) [CAS No. 2104-64-5]

Details

• Journal Article:
  National Institute for Occupational Safety and Healtho
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  Although the mathematical model did not predict EPN to be absorbed through the skin following dermal exposure, toxicokinetic data on cats [Abou-Donia et al. 1983a; 1983d, 1983e], data from acute toxicity studies in rats [Gaines 1969], rabbits [Hodge et al 1954], and cats [Abou-Donia et al. 1983b], and findings in subchronic studies of hens and cats [Abou-Donia et al. 1983b, 1983c] indicate EPN is absorbed through skin, is systemically available, and has the potential to cause systemic effects, including fatality, following dermal exposure. No in vivo or in vitro studies of humans or animals that evaluated the potential of EPN to cause direct skin effects or skin sensitization were identified. Therefore, on the basis of these assessments, EPN is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for EPN previously issued by NIOSH and other organizations. The equivalent dermal designation for EPN, according to the Globally Harmonized System (GHS) for Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Armin Dermatitis, Occupational Environmental Exposure Epidemiology Hazardous Substances Laboratories Mortality Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Skin Skin Absorption Skin Diseases Toxicology

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• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute-toxicity; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Lethal-dose; Dermal-exposure; Skin absorption; Exposure assessment; EPN; Phenyls; Thioates; Mortality data; Mathematical models; Biological effects; Health effects
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-136, 2017 Apr; :1-9
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20049607
• NTIS Accession Number:
  PB2017-102217
• CAS Registry Number:
  O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate (CAS RN 2104-64-5)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:55a467699a728410c925fab0d8d8ed2e89e8ddab4cb4dcd37fac17e8010ea34d1d0f5ebe363b101ccd83018077e8e2371b084065b9dc98d253105425effb964a
• Download URL:
  https://stacks.cdc.gov/view/cdc/45054/cdc_45054_DS1.pdf
• File Type:
  [PDF - 234.43 KB ]