Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Mullins, Kristin E. ; Hang, Jun ; Clifford, Robert J. ; Onmus-Leone, Fatma ; Yang, Yu ; ... More +
Mullins, Kristin E. ; Hang, Jun ; Clifford, Robert J. ; Onmus-Leone, Fatma ; Yang, Yu ; Jiang, Ju ; Leguia, Mariana ; Kasper, Matthew R. ; Maguina, Ciro ; Lesho, Emil P. ; Jarman, Richard G. ; Richards, Allen ; Blazes, David Less -
Description:
The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living in Caraz, Peru, during a clinical trial of treatment for bartonellosis. Three B. ancashensis strains were analyzed by using whole-genome restriction mapping and high-throughput pyrosequencing. Genome-wide comparative analysis of Bartonella species showed that B. ancashensis has features seen in modern and ancient lineages of Bartonella species and is more related to B. bacilliformis. The divergence between B. ancashensis and B. bacilliformis is much greater than what is seen between known Bartonella genetic lineages. In addition, B. ancashensis contains type IV secretion system proteins, which are not present in B. bacilliformis. Whole-genome analysis indicates that B. ancashensis might represent a distinct Bartonella lineage phylogenetically related to B. bacilliformis.
Subject:
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Adolescent
Adult
Bartonella
Bartonella Infections
Child
Child, Preschool
Female
Genome, Bacterial
Humans
Infant
Male
Middle Aged
Phylogeny
Young Adult

Source:
Emerg Infect Dis. 23(3):430-438.
Pubmed ID:
28221130
Pubmed Central ID:
PMC5382735
Document Type:
Journal Article
Place as Subject:
Peru
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:202fa3bf9ff798dfb11c0926503ecf39479913157f565cfd602bbee4c91d190f
File Type:

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