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Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease
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Sep 2016
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Source: J Occup Environ Med. 58(9):855-860.
Details:
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Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objective
Beryllium workers may better understand their genetic susceptibility to chronic beryllium disease (CBD) expressed as population-based prevalence, rather than odds ratios from case-control studies.
Methods
We calculated CBD prevalences from allele-specific DNA sequences of 853 workers for Human Leukocyte Antigen (HLA)-DPB1 genotypes and groups characterized by number of E69-containing alleles and by calculated surface electronegativity of HLA-DPB1.
Results
Of 18 groups of at least 10 workers with specific genotypes, CBD prevalence was highest, 72.7%, for the HLA-DPB1*02:01:02/DPB1*17:01 genotype. Population-based grouped genotypes with two E69 alleles wherein one allele had −9 surface charge had a beryllium sensitization (BeS) of 52.6% and a CBD prevalence of 42.1%.
Conclusions
The high CBD and BeS prevalences associated with −9-charged E69 alleles and two E69s suggest that workers may benefit from knowing their genetic susceptibility in deciding whether to avoid future beryllium exposure.
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Subjects:
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Source:
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Pubmed ID:27414009
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Pubmed Central ID:PMC5339739
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Document Type:
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Funding:
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Volume:58
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Issue:9
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Main Document Checksum:
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Download URL:
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File Type:
[PDF-193.66 KB]
Supporting Files
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