Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Kreiss, Kathleen ; Fechter-Leggett, Ethan D. ; McCanlies, Erin C. ; Schuler, Christine R. ; Weston, Ainsley
• Description:
  Objective
  
  Beryllium workers may better understand their genetic susceptibility to chronic beryllium disease (CBD) expressed as population-based prevalence, rather than odds ratios from case-control studies.
  
  Methods
  
  We calculated CBD prevalences from allele-specific DNA sequences of 853 workers for Human Leukocyte Antigen (HLA)-DPB1 genotypes and groups characterized by number of E69-containing alleles and by calculated surface electronegativity of HLA-DPB1.
  
  Results
  
  Of 18 groups of at least 10 workers with specific genotypes, CBD prevalence was highest, 72.7%, for the HLA-DPB1*02:01:02/DPB1*17:01 genotype. Population-based grouped genotypes with two E69 alleles wherein one allele had −9 surface charge had a beryllium sensitization (BeS) of 52.6% and a CBD prevalence of 42.1%.
  
  Conclusions
  
  The high CBD and BeS prevalences associated with −9-charged E69 alleles and two E69s suggest that workers may benefit from knowing their genetic susceptibility in deciding whether to avoid future beryllium exposure.
  
  
• Subjects:
  Berylliosis/genetics Beryllium Chronic Disease Genotype HLA-DP Beta-Chains/genetics Humans
• Source:
  J Occup Environ Med. 58(9):855-860.
• Pubmed ID:
  27414009
• Pubmed Central ID:
  PMC5339739
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  58
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4dca65f676096b1987f006c40fdcbd3a88019eb7d96a772010e5d26c1eb6b360
• Download URL:
  https://stacks.cdc.gov/view/cdc/44526/cdc_44526_DS1.pdf
• File Type:
  [PDF - 193.66 KB ]