Details:

Alternative Title:
Environ Res
Publisher's site:
http://dx.doi.org/10.1016/j.envres.2016.12.029
Personal Author:
Callahan, Catherine L. ; Vena, John E. ; Green, Joseph ; Swanson, Mya ; Mu, Lina ; ... More +
Callahan, Catherine L. ; Vena, John E. ; Green, Joseph ; Swanson, Mya ; Mu, Lina ; Bonner, Matthew R. Less -
Description:
Fish consumption is hypothesized to reduce the risk of colorectal cancer. Nonetheless, consuming sport fish from the Great Lakes increases exposure to certain persistent organic pollutants, namely polychlorinated biphenyls (PCBs) and organochlorine insecticides, which may increase the risk of cancer. Evidence that exposure to persistent organic pollutants is associated with colorectal cancer is sparse. We examined colorectal cancer incidence in the New York State Angler Cohort Study (NYSACS), a prospective cohort of 17,110 anglers and spouses age 18-40 years at enrollment. In 1991, participants completed a mailed self-administered questionnaire that ascertained the number of years that fish from Lake Ontario were consumed, as well as potential confounders. Forty-one histologically confirmed first primary incident colorectal cancers diagnosed as of December 31, 2008 were identified via the New York State Cancer Registry. Vital status was ascertained by linkage with the Social Security Administration Death File. Rate ratios (RR) and 95% confidence intervals (CI) were calculated with Poisson regression, adjusting for age, pack-years of smoking, and sex. Compared with never consumers, colorectal cancer incidence was statistically non-significantly lower among consumers of Lake Ontario sport fish (RR=0.66; 95% CI: 0.35; 1.24). Incidence of colon cancer was lower among Lake Ontario sport fish consumers (RR=0.45, 95%CI: 0.20; 1.00). We did not observe any evidence of effect measure modification by sex or age. Although consumption of Lake Ontario sport fish may have an inverse association with colorectal cancer risk, inferences are complicated by a small number of cases and a lack of information regarding potential confounders including other dietary factors. However, our results do not provide support for the hypothesis that consumption of contaminated sport fish increases the risk of colorectal cancer.
Subject:
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Adolescent Adult Animals Colorectal Neoplasms Environmental Exposure Female Fishes Food Contamination Humans Lakes Male Organic Chemicals Prospective Studies Seafood Water Pollutants, Chemical Young Adult
Source:
Environ Res. 154:86-92.
Pubmed ID:
28040638
Pubmed Central ID:
PMC5328926
Document Type:
Journal Article
Funding:
R01 TS000077/TS/ATSDR CDC HHS/United States ; R25 CA113951/CA/NCI NIH HHS/United States
R01 TS000077/TS/ATSDR CDC HHS/United States ; R25 CA113951/CA/NCI NIH HHS/United States Less -
Place as Subject:
New York
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6c92967f14cd1854d2133739c0f5c2533b4a6b500d5e08af45e8edad1d778f51
Download URL:
https://stacks.cdc.gov/view/cdc/44434/cdc_44434_DS1.pdf
File Type:

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